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Membrane processing effect of blackberry (Rubus adenotrichos) on cytotoxic and pro-apoptotic activities against cancer cell lines
dc.creator | Madrigal Gamboa, Verónica | |
dc.creator | Jiménez Arias, Johan | |
dc.creator | Hidalgo Muñoz, Olman | |
dc.creator | Quesada Mora, Silvia | |
dc.creator | Pérez Carvajal, Ana Mercedes | |
dc.creator | Azofeifa Cordero, Gabriela | |
dc.date.accessioned | 2022-11-10T20:15:07Z | |
dc.date.available | 2022-11-10T20:15:07Z | |
dc.date.issued | 2021-04-23 | |
dc.identifier.citation | https://ifst.onlinelibrary.wiley.com/doi/10.1111/jfpp.15575 | es_ES |
dc.identifier.issn | 1745-4549 | |
dc.identifier.uri | https://hdl.handle.net/10669/87676 | |
dc.description.abstract | Berries are considered an important source of bioactive compounds. In the tropics, Rubus adenotrichos is commonly cultivated, and it is consumed mostly in processed forms. This study assessed the effect of industrial processing in the polyphenol composition and cytotoxic activity against cancer cell lines of four samples of blackberry: fruit, pulp, microfiltered juice, and diafiltered juice. The juice samples showed differences in phenolic concentrations compared with the fruit samples; whereas anthocyanins undergo a 30% to 32% decrease in concentration, the ellagitannins decreased a 93% to 95%. The cytotoxicity assays were performed in stomach (AGS), colon (SW-620), liver (HepG2), and skin (SK-Mel-28) cancer cell lines, and only the fruit and pulp polyphenols achieved IC50 below 200 μg/ml. The IC50 values for the juice samples were over 300 μg/ml. Besides, the pro-apoptotic activity of the fruit polyphenols was assessed and up to 41% of the cells showed early apoptosis with phenolic treatments between 84 to 211 μg/ml. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[422-B7-099]/UCR/Costa Rica | es_ES |
dc.language.iso | eng | es_ES |
dc.source | Journal of Food Processing and Preservation, Vol.45 (6), pp. 1-12 | es_ES |
dc.subject | Berries | es_ES |
dc.subject | Rubus adenotrichos | es_ES |
dc.subject | Polyphenol | es_ES |
dc.subject | Blackberry | es_ES |
dc.subject | Phenolic concentration | es_ES |
dc.title | Membrane processing effect of blackberry (Rubus adenotrichos) on cytotoxic and pro-apoptotic activities against cancer cell lines | es_ES |
dc.type | artículo original | es_ES |
dc.identifier.doi | 10.1111/jfpp.15575 | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR) | es_ES |
dc.identifier.codproyecto | 422-B7-099 |
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