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dc.creatorGonzález Hernández, Jerson
dc.creatorOtt, Colby Edward
dc.creatorArcos Martínez, María Julia
dc.creatorColina, Álvaro
dc.creatorHeras, Aránzazu
dc.creatorAlvarado Gámez, Ana Lorena
dc.creatorUrcuyo Solórzano, Roberto
dc.creatorArroyo Mora, Luis E.
dc.date.accessioned2022-08-08T15:37:33Z
dc.date.available2022-08-08T15:37:33Z
dc.date.issued2021-12-31
dc.identifier.citationhttps://www.mdpi.com/1424-8220/22/1/295es_ES
dc.identifier.issn1424-8220
dc.identifier.urihttps://hdl.handle.net/10669/87135
dc.description.abstractThe synthetic cathinones mephedrone (4-MMC) and 4-methylethcathinone (4-MEC) are two designer drugs that represent the rise and fall effect of this drug category within the stimulants market and are still available in several countries around the world. As a result, the qualitative and quantitative determination of ‘legal highs’, and their mixtures, are of great interest. This work explores for the first time the spectroelectrochemical response of these substances by coupling cyclic voltammetry (CV) with Raman spectroscopy in a portable instrument. It was found that the stimulants exhibit a voltammetric response on a gold screen-printed electrode while the surface is simultaneously electro-activated to achieve a periodic surface-enhanced Raman spectroscopy (SERS) substrate with high reproducibility. The proposed method enables a rapid and reliable determination in which both substances can be selectively analyzed through the oxidation waves of the molecules and the characteristic bands of the electrochemical SERS (EC-SERS) spectra. The feasibility and applicability of the method were assessed in simulated seized drug samples and spiked synthetic urine. This time-resolved spectroelectrochemical technique provides a cost-effective and user-friendly tool for onsite screening of synthetic stimulants in matrices with low concentration analytes for forensic applications.es_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Innovación, Ciencia, Tecnología y Telecomunicaciones//MICITT/Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceSensors; Vol. 22 Núm. 1: 2022es_ES
dc.subjectSpectroelectrochemistryes_ES
dc.subjectSynthetic cathinoneses_ES
dc.subjectRaman SERSes_ES
dc.subject4-MMCes_ES
dc.subject4-MECes_ES
dc.titleRapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopyes_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.3390/s22010295
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES


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