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dc.creatorRojas Garbanzo, Carolina
dc.creatorRodríguez, Lyanne
dc.creatorPérez Carvajal, Ana Mercedes
dc.creatorMayorga Gross, Ana Lucía
dc.creatorVásquez Chaves, Víctor
dc.creatorFuentes Quinteros, Eduardo
dc.creatorPalomo, Iván
dc.date.accessioned2022-07-28T18:14:40Z
dc.date.available2022-07-28T18:14:40Z
dc.date.issued2021
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0963996920310954?via%3Dihubes_ES
dc.identifier.issn0963-9969
dc.identifier.urihttps://hdl.handle.net/10669/87064
dc.description.abstractIn Costa Rica, two species of Psidium fruits, P. guajava and P. friedrichsthalianum, are widely consumed as food and used in folk medicine. Although studies have revealed the health effects of these fruits, there has been little research showing the antiplatelet activity of these species. This work evaluated the antiplatelet potential of aqueous extracts made from leaves and fruits of pink guava and Costa Rican guava. Platelet aggregation was induced by the platelet agonists ADP, TRAP-6, collagen and PMA. Platelet activation and secretion were studied using flow cytometry. The chemical profiles of the four extracts were characterized using UPLC-DAD-ESI-QTOF-MS. The studies revealed that the aqueous extracts of leaves and fruits of P. guajava and P. friedrichsthalianum inhibited platelet aggregation induced by ADP (4 µM), TRAP-6 (5 µM), collagen (1 µg mL−1) and PMA (100 nM), and the effect was dependent on the extract concentration. Extracts of leaves and fruits of pink guava and Costa Rican guava reduced secretion of P-selectin and activation of GP IIb/IIIa. The extracts of leaves and fruits of pink guava and Costa Rican guava proved to be a rich source of phenolic compounds, mainly quercetin aglycones and proanthocyanidins derived from (epi) catechin units. Other compounds such as ellagitannins, and benzophenones were also putatively identified. This research showed that P. guajava and P. friedrichsthalianum could potentially be used for the prevention of thrombotic events.es_ES
dc.description.sponsorshipRed Iberoamericana de Alimentos Autóctonos Subutilizados/[ALSUB-CYTED, 118RT0543]//Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[735-B8-770]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[735-B9-035]/UCR/Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceFood Research International; Vol. 141: 2021es_ES
dc.subjectBioactive compoundses_ES
dc.subjectAnti-thrombotices_ES
dc.subjectCosta Rican guavaes_ES
dc.subjectPsidium friedrichsthaliumes_ES
dc.subjectPink guavaes_ES
dc.subjectPsidium guajavaes_ES
dc.subjectMass spectrometryes_ES
dc.titleAnti-platelet activity and chemical characterization by UPLC-DAD-ESI-QTOF-MS of the main polyphenols in extracts from Psidium leaves and fruitses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.foodres.2020.110070
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA)es_ES
dc.identifier.codproyecto735-B8-770
dc.identifier.codproyecto735-B9-035


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