Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC
artículo original
Fecha
2022Autor
Sáenz Castillo, Antonio
Sanabria Chinchilla, Jean
García Piñeres, Alfonso J.
Tamayo Castillo, Giselle
Metadatos
Mostrar el registro completo del ítemResumen
A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic
acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined
in an LPS stimulated RAW 264.7 murine macrophage assay with IC50 values for inhibition of NO
production of (18 ± 3) and (26 ± 5) μM, for 1 and 2, respectively. These compounds do not inhibit NO production
by a competitive inhibition of the iNOS enzyme and show anti-inflammatory properties by lowering the
expression of pro-inflammatory genes (TNF-α, IL-1β, CXCL2 and CCL2), as determined by qRT-PCR. Electrochemical
measurements using cyclic voltammetry (CV) show that compound 1 exhibits anti-oxidant properties.
This is the first phytochemical study of this plant, and we report a preliminary study of the biological activity of
the isolated compounds.
External link to the item
10.1016/j.phytol.2021.10.018Colecciones
- Química [360]