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dc.creatorGonzález Corrales, Daniela
dc.creatorMonge Quirós, Tatiana
dc.creatorChavarría Rojas, Marianela
dc.creatorRojas Campos, Norman
dc.creatorCruz Sibaja, Wendy
dc.creatorMadrigal Redondo, German
dc.date.accessioned2022-07-19T17:11:50Z
dc.date.available2022-07-19T17:11:50Z
dc.date.issued2021-02-27
dc.identifier.citationhttps://revistas.udea.edu.co/index.php/vitae/article/view/341703es_ES
dc.identifier.issn0121-4004
dc.identifier.issn2145-2660
dc.identifier.urihttps://hdl.handle.net/10669/86981
dc.description.abstractBackground: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs. Essential oils have shown antimicrobial activity against bacteria causing periodontal disease; therefore, they are considered potential therapeutic agents. Objectives: The main objective was to formulate and evaluate the antimicrobial activity of a 0.2% chlorhexidine canine mouthwash with essential oils. Methods: Three microemulsion formulations were obtained by constructing a pseudo-ternary phase diagram using the phase titration method. Different surfactant agents were evaluated, and hydrogenated castor oil was selected as the emulsifier agent. The antimicrobial activity of oregano essential oil (Origanum vulgare), thyme essential oil (Thymus vulgaris), and the three formulations were evaluated against Staphylococcus aureus, Streptococcus mutans, Streptococcus salivarius, and Escherichia coli. Results: Pure thyme and oregano essential oils showed higher antimicrobial activity than a 0,2% chlorhexidine solution. The formulations with essential oils plus chlorhexidine and chlorhexidine alone showed antimicrobial activity. The formulation containing only essential oils did not show antimicrobial activity. Conclusions: A canine mouthwash was formulated with chlorhexidine and thyme and oregano essential oil. Based on the evaluation of antimicrobial activity, two of the proposed formulations could be a therapeutic option to reduce the risk and prevent periodontal disease in canines.es_ES
dc.language.isoenges_ES
dc.sourceJournal Vitae; Vol. 28 Núm. 01: 2021es_ES
dc.subjectPeriodontitises_ES
dc.subjectMicroemulsiones_ES
dc.subjectOreganoes_ES
dc.subjectThymees_ES
dc.subjectChlorhexidinees_ES
dc.subjectEssential oiles_ES
dc.titleFormulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oilses_ES
dc.title.alternativeFormulación y evaluación de la actividad antimicrobiana de un enjuague bucal canino de clorhexidina al 2% y aceites esencialeses_ES
dc.typeartículo originales_ES
dc.identifier.doi10.17533/udea.vitae.v28n1a341703
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


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