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Development of novel microstructured lipid carriers for dissolution rate enhancement of albendazole
dc.creator | Castro Alpízar, Jose Alexis | |
dc.creator | Vargas Monge, Ronny | |
dc.creator | Madrigal Redondo, German | |
dc.creator | Pacheco Molina, Jorge A. | |
dc.date.accessioned | 2021-11-05T19:30:57Z | |
dc.date.available | 2021-11-05T19:30:57Z | |
dc.date.issued | 2020-11-07 | |
dc.identifier.citation | https://innovareacademics.in/journals/index.php/ijap/article/view/34782 | |
dc.identifier.issn | 0975-7058 | |
dc.identifier.uri | https://hdl.handle.net/10669/85113 | |
dc.description.abstract | Objective: This study aimed to develop a microstructured lipid carrier that improves the rate of dissolution of the active pharmaceutical ingredient (API) Albendazole. Methods: A solvent diffusion method was used for the development of microstructured lipid carriers. The developed carriers were characterized by optical microscopy, infrared spectroscopy, differential scanning calorimetry (DSC), X-ray diffractometry (XRD), and dissolution testing. Results: The morphology of the carriers was irregular, and their size tends to decrease with the addition of modifiers. Furthermore, the diffractograms and the thermograms indicated a loss of crystallinity. The thermograms and infrared spectra showed that there are not chemical incompatibilities between the API and the excipients. When the lipid carrier particles were modified with Aerosil® 200 (specifically when using this excipient at a level of 6% w/w), dissolution was increased up to 85.96±1.17 % of the drug content as per USP test for Albendazole tablets in comparison with 36.13±0.52 % for a lipid carrier formulation without modifiers. Conclusion: It was demonstrated that it is possible to develop a modified lipid carrier that improves the dissolution rate of an API with a low solubility, which was related to the amorphization of the API crystalline structure. | es_ES |
dc.language.iso | eng | es_ES |
dc.source | International Journal of Applied Pharmaceutics 12/6, 2020 | es_ES |
dc.subject | Albendazole | es_ES |
dc.subject | Microstructured lipid carrier | es_ES |
dc.subject | Dissolution | es_ES |
dc.subject | Crystalline structure | es_ES |
dc.title | Development of novel microstructured lipid carriers for dissolution rate enhancement of albendazole | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.22159/ijap.2020v12i6.34782 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR) | es_ES |
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