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dc.creatorRojas Carvajal, Mijail
dc.creatorQuesada Yamasaki, Daniel
dc.creatorBrenes Sáenz, Juan Carlos
dc.date.accessioned2021-07-02T15:25:23Z
dc.date.available2021-07-02T15:25:23Z
dc.date.issued2021-02-17
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S2215016121000649?via%3Dihubes_ES
dc.identifier.issn2215-0161
dc.identifier.urihttps://hdl.handle.net/10669/83844
dc.description.abstractWithin behavioral neuroscience, subjects used to be randomly assigned to the experimental groups based on the premise that interindividual variability will be homogeneously distributed. However, the equivalence offered by randomization diminishes in small samples, which is the case for most experiments in the field. In rodents, it is well-recognized that individual differences in psychomotor reactivity, risk-assessment behaviors, and emotional responsiveness modulate the effects of different pharmacological and non-pharmacological treatments. For that reason, knowing such differences before the experiment provides highly valuable information for balancing the groups so that the interindividual variability is equally distributed within the groups without excluding subjects as far as possible. Because unconditioned anxiety tests such as the open-field (OF) and the elevated plus-maze are commonly used within experimental procedures, we developed a strategy to explore the rat’s behavioral phenotype by assessing it in a very innocuous testing context: a housing cage. •We offer a very straightforward protocol for assessing spontaneous, novelty-induced reactivity in rodents. •We describe its implementation, analysis, and use, as well as some suggestions about key behavioral readouts for the group allocation procedure. •The current protocol provides an alternative strategy to assess a reasonably wide range of behavioral outcomes, most of which are of great interest in modeling different neuropsychiatric disorders.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[723-B9-197]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[837-B7-603]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[837-B8-123]/UCR/Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceMethodsX, vol.8, pp.1-15es_ES
dc.subjectScreening testes_ES
dc.subjectUnconditioned anxietyes_ES
dc.subjectBehavioral analysises_ES
dc.subjectUltrasonic vocalizationses_ES
dc.subjectRisk-assessmentes_ES
dc.subjectGroominges_ES
dc.subjectBalanced group assignmentes_ES
dc.titleThe cage test as an easy way to screen and evaluate spontaneous activity in preclinical neuroscience studieses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.mex.2021.101271
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.identifier.codproyecto723-B9-197
dc.identifier.codproyecto837-B7-603
dc.identifier.codproyecto837-B8-123


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