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dc.creatorCalvete Chornet, Juan José
dc.creatorBonilla Murillo, Fabián
dc.creatorGranados Martínez, Sofía
dc.creatorSanz, Libia
dc.creatorLomonte, Bruno
dc.creatorSasa Marín, Mahmood
dc.date.accessioned2021-03-24T15:07:19Z
dc.date.available2021-03-24T15:07:19Z
dc.date.issued2020
dc.identifier.citationhttps://www.sciencedirect.com/science/article/abs/pii/S1874391920302505?via%3Dihub
dc.identifier.issn1874-3919
dc.identifier.urihttps://hdl.handle.net/10669/83139
dc.description.abstractThe Duvernoy's gland secretory proteome of the false coral snake Rhinobothryum bovallii (Costa Rica), unveiled applying bottom-up venomics, comprises a handful of toxins belonging to only three protein families, three-finger toxin (3FTx), cysteine-rich secretory protein (CRISP), and snake venom metalloprotease (PIII-SVMP). Except for small differences in the relative abundance of the PIII-SVMPs, which may be due to individual variability, no evidence of geographic variability or ontogenetic changes was found among the venom proteomes of the juvenile and adult R. bovallii snakes sampled. Major monomeric (86.5%mol) and minor dimeric (2.8%mol) 3FTxs dominate the toxin arsenal of the Costa Rican false coral snake. The remaining 10.7% of the venom proteome comprises CRISP (8.2%) and PIII-SVMP (2.4%) molecules. In vivo lethality assays showed that R. bovallii produces venom that is non-toxic towards mammalian prey, and which exerts a different toxic effect on domestic chicken chicks and baby green iguana. Toxicovenomic analysis of R. bovallii venom in the iguana model identified two 3FTx RP-HPLC fractions that faithfully mimicked the irreversible immobilizing effect of the whole venom.es_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades/[BFU2017-89103-P]/MICIU/Españaes_ES
dc.language.isoenges_ES
dc.sourceJournal of Proteomics, vol.225, pp.1-11es_ES
dc.subjectSnake venomicses_ES
dc.subjectRear-fanged snakees_ES
dc.subjectRhinobothryum bovalliies_ES
dc.subjectDuvernoy's gland secretiones_ES
dc.subjectToxicovenomicses_ES
dc.subjectDiapsid-specific venom toxines_ES
dc.subjectColubridae 3FTxes_ES
dc.titleVenomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal modelses_ES
dc.typeartículo científico
dc.identifier.doi10.1016/j.jprot.2020.103882
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES


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