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dc.creatorBrenes Sáenz, Juan Carlos
dc.creatorFornaguera Trías, Jaime
dc.creatorSequeira Cordero, Andrey
dc.date.accessioned2020-12-08T16:56:46Z
dc.date.available2020-12-08T16:56:46Z
dc.date.issued2020
dc.identifier.citationhttps://www.frontiersin.org/articles/10.3389/fphar.2020.00804/full
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/10669/82150
dc.description.abstractWe assessed the antidepressant-like effects of environmental enrichment (EE) and physical exercise (PE) compared with the selective serotonin reuptake inhibitor fluoxetine against the depression-related neurobehavioral alterations induced by postweaning social isolation (SI) in rats. After 1 month of SI, rats were submitted to PE (treadmill), EE, or fluoxetine (10 mg/kg), which were compared with naïve SI and grouphoused rats. After 1 month, behavior was analyzed in the open field (OFT), the sucrose preference (SPT), and the forced swimming (FST) tests. Afterward, the hippocampal serotonin contents, its metabolite, and turnover were measured. SI induced a depressionrelated phenotype characterized by a marginal bodyweight gain, anxiety, anhedonia, behavioral despair, and alterations of serotonin metabolism. EE produced the widest and largest antidepressive-like effect, followed by PE and fluoxetine, which were almost equivalent. The treatments, however, affected differentially the neurobehavioral domains investigated. EE exerted its largest effect on anhedonia and was the only treatment inducing anxiolytic-like effects. Fluoxetine, in contrast, produced its largest effect on serotonin metabolism, followed by its anti-behavioral despair action. PE was a middleground treatment with broader behavioral outcomes than fluoxetine, but ineffective to reverse the serotonergic alterations induced by SI. The most responsive test to the treatments was the FST, followed closely by the SPT. Although OFT locomotion and body weight varied considerably between groups, they were barely responsive to PE and fluoxetine. From a translational standpoint, our data suggest that exercise and recreational activities may have broader health benefits than antidepressants to overcome confinement and the consequences of chronic stress.es_ES
dc.language.isoen_USes_ES
dc.sourceFrontiers in Pharmacology, vol.11, pp.1-12es_ES
dc.subjectSocial isolationes_ES
dc.subjectEnvironmental enrichmentes_ES
dc.subjectPhysical exercisees_ES
dc.subjectAntidepressant effectes_ES
dc.subjectSerotonines_ES
dc.subjectHippocampuses_ES
dc.subjectTreadmilles_ES
dc.subjectDepressiones_ES
dc.titleEnvironmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Ratses_ES
dc.typeartículo científico
dc.identifier.doi10.3389/fphar.2020.00804
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.codproyecto742-B4-240
dc.identifier.codproyecto723-B7-610


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