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dc.creatorCastillo Henríquez, Luis
dc.creatorMadrigal Redondo, German
dc.creatorVargas Zúñiga, Rolando
dc.creatorCarazo Berrocal, Gustavo
dc.date.accessioned2020-04-28T19:38:54Z
dc.date.available2020-04-28T19:38:54Z
dc.date.issued2019
dc.identifier.citationhttp://jddtonline.info/index.php/jddt/article/view/2359
dc.identifier.issn2250-1177
dc.identifier.urihttps://hdl.handle.net/10669/80936
dc.description.abstractDesign of Experiments (DoE) is a statistical model that aims to determine if the factors under study affect the response, and if so, it determines the conditions under which this variable of interest can be optimized. In terms of pharmaceutical technology, independent variables are usually factors of the formulation, while dependent variables are properties of the product or parameters that indicate the performance of the process. Precisely, the dissolution test is a tool of interest for the developers of medicines since it allows them to evaluate the performance of a formulation designed in a solid pharmaceutical form, such as tablets. The present investigation used the design of experiments to establish and optimize the conditions of the dissolution test of a 10 mg Rupatadine fumarate tablets formulation, resulting in the use of HCl 0,1 N (pH 1) dissolution medium and a rotation speed of 100 rpm for the apparatus II USP, which allow the analysis of the product in a reproducible and reliable way.es_ES
dc.language.isoen_USes_ES
dc.sourceJournal of Drug Delivery & Therapeutics, vol.9(1S), pp.331-336es_ES
dc.subjectAnalysis of varianceses_ES
dc.subjectDesign of experimentses_ES
dc.subjectDissolution testes_ES
dc.subjectFactorial designes_ES
dc.subjectRupatadine Fumaratees_ES
dc.subjectTabletses_ES
dc.subjectTest conditionses_ES
dc.titleDesign of Experiments for the Establishment of the Dissolution Test Conditions of Rupatadine Fumarate 10 mg tabletses_ES
dc.typeartículo original
dc.identifier.doi10.22270/jddt.v9i1-s.2359
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


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