Mostrar el registro sencillo del ítem

dc.creatorPetschenka, Georg
dc.creatorFei, Colleen S.
dc.creatorAraya Barrantes, Juan José
dc.creatorSchröder, Susanne
dc.creatorTimmermann, Barbara N.
dc.creatorAgrawal, Anurag A.
dc.date.accessioned2020-04-27T20:03:07Z
dc.date.available2020-04-27T20:03:07Z
dc.date.issued2018
dc.identifier.citationhttps://www.frontiersin.org/articles/10.3389/fpls.2018.01424/full
dc.identifier.issn1664-462X
dc.identifier.urihttps://hdl.handle.net/10669/80930
dc.description.abstractA major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well with cardiac glycosides (inhibitors of animal NaC/KC-ATPases) from its milkweed host plants, but selective inhibition of its NaC/KC-ATPase by different compounds has not been previously tested. We applied 17 cardiac glycosides to the D. plexippus-NaC/KC-ATPase and to the more susceptible NaC/KC-ATPases of two non-adapted insects (Euploea core and Schistocerca gregaria). Structural features (e.g., sugar residues) predicted in vitro inhibitory activity and comparison of insect NaC/KC-ATPases revealed that the monarch has evolved a highly resistant enzyme overall. Nonetheless, we found evidence for relative selectivity of individual cardiac glycosides reaching from 4- to 94-fold differences of inhibition between non-adapted NaC/KC-ATPase and D. plexippus-NaC/KC-ATPase. This toxin receptor specificity suggests a mechanism how plants could target herbivores selectively and thus provides a strong basis for pairwise coevolutionary interactions between plants and herbivorous insects.es_ES
dc.description.sponsorshipGerman Research Foundation/[GP, PE 2059/1-1]/DFG/Alemaniaes_ES
dc.description.sponsorshipUS National Science Foundation/[AA,DEB-1619885]/NSF/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceRevista Frontiers in Plant Science, vol.9(1424), pp.1-13es_ES
dc.subjectNa+/K+ -ATPasees_ES
dc.subjectMonarch butterflyes_ES
dc.subjectCardenolidees_ES
dc.subjectCardiac glycosidees_ES
dc.subjectPhytochemical diversityes_ES
dc.subjectStructure–activity relationshipes_ES
dc.subjectToxin–receptor interactiones_ES
dc.subjectResistancees_ES
dc.titleRelative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insectses_ES
dc.typeartículo original
dc.identifier.doi10.3389/fpls.2018.01424
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)es_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem