Mostrar el registro sencillo del ítem
Dengue Virus Infection of Primary Human Smooth Muscle Cells
dc.creator | Arias Arias, Jorge Luis | |
dc.creator | Vega Aguilar, Francisco | |
dc.creator | Corrales Aguilar, Eugenia | |
dc.creator | Hun Opfer, Ruchilia Laya | |
dc.creator | Loría Masis, Gilbert David | |
dc.creator | Mora Rodríguez, Rodrigo Antonio | |
dc.date.accessioned | 2019-01-29T16:11:08Z | |
dc.date.available | 2019-01-29T16:11:08Z | |
dc.date.issued | 2018-11-05 | |
dc.identifier.citation | http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0175 | |
dc.identifier.issn | 1476-1645 | |
dc.identifier.uri | https://hdl.handle.net/10669/76502 | |
dc.description.abstract | Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components other than endothelial cells are lacking. Dengue virus infection of vascular smooth muscle cells, which play a physiological compensatory response to hypotension in arteries and arterioles, has not been characterized, thus precluding our understanding of the role of these vascular components in dengue pathogenesis. Therefore, we studied the permissiveness of primary human umbilical artery smooth muscle cells (HUASMC) to DENV 1-4 infection and compared with the infection in the previously reported primary human umbilical vein endothelial cells (HUVEC) and the classically used, non-transformed, and highly permissive Lilly Laboratories Cell-Monkey Kidney 2 cells. Our results show that HUASMC are susceptible and productive to infection with the four DENV serotypes, although to a lesser extent when compared with the other cell lines. This is the first report of DENV permissiveness in human smooth muscle cells, which might represent an unexplored pathophysiological contributor to the vascular collapse observed in severe human dengue infection. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[803-A5-025]/UCR/Costa Rica | es_ES |
dc.language.iso | en_US | es_ES |
dc.relation.ispartof | ||
dc.source | The American Journal of Tropical Medicine and Hygiene, vol.99(6), pp. 1451-1457 | es_ES |
dc.subject | Infections | es_ES |
dc.subject | Smooth muscle cells | es_ES |
dc.subject | Vascular problems | es_ES |
dc.subject | Dengue | es_ES |
dc.title | Dengue Virus Infection of Primary Human Smooth Muscle Cells | es_ES |
dc.type | artículo original | |
dc.date.updated | 2019-01-11T21:57:07Z | |
dc.identifier.doi | 10.4269/ajtmh.18-0175 | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET) | es_ES |
dc.identifier.codproyecto | 803-A5-025 |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Microbiología [1171]