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dc.creatorArias Arias, Jorge Luis
dc.creatorVega Aguilar, Francisco
dc.creatorCorrales Aguilar, Eugenia
dc.creatorHun Opfer, Ruchilia Laya
dc.creatorLoría Masis, Gilbert David
dc.creatorMora Rodríguez, Rodrigo Antonio
dc.date.accessioned2019-01-29T16:11:08Z
dc.date.available2019-01-29T16:11:08Z
dc.date.issued2018-11-05
dc.identifier.citationhttp://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0175es_ES
dc.identifier.issn1476-1645
dc.identifier.urihttps://hdl.handle.net/10669/76502
dc.description.abstractDengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components other than endothelial cells are lacking. Dengue virus infection of vascular smooth muscle cells, which play a physiological compensatory response to hypotension in arteries and arterioles, has not been characterized, thus precluding our understanding of the role of these vascular components in dengue pathogenesis. Therefore, we studied the permissiveness of primary human umbilical artery smooth muscle cells (HUASMC) to DENV 1-4 infection and compared with the infection in the previously reported primary human umbilical vein endothelial cells (HUVEC) and the classically used, non-transformed, and highly permissive Lilly Laboratories Cell-Monkey Kidney 2 cells. Our results show that HUASMC are susceptible and productive to infection with the four DENV serotypes, although to a lesser extent when compared with the other cell lines. This is the first report of DENV permissiveness in human smooth muscle cells, which might represent an unexplored pathophysiological contributor to the vascular collapse observed in severe human dengue infection.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[803-A5-025]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.relation.ispartof
dc.sourceThe American Journal of Tropical Medicine and Hygiene, vol.99(6), pp. 1451-1457es_ES
dc.subjectInfectionses_ES
dc.subjectSmooth muscle cellses_ES
dc.subjectVascular problemses_ES
dc.subjectDenguees_ES
dc.titleDengue Virus Infection of Primary Human Smooth Muscle Cellses_ES
dc.typeartículo científicoes_ES
dc.date.updated2019-01-11T21:57:07Z
dc.identifier.doi10.4269/ajtmh.18-0175
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.identifier.codproyecto803-A5-025


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