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dc.creatorLaustsen, Andreas Hougaard
dc.creatorEngmark, Mikael Gerling
dc.creatorMilbo, Christina
dc.creatorJohannesen, Jonás
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.creatorLohse, Brian
dc.date.accessioned2018-05-18T15:59:24Z
dc.date.available2018-05-18T15:59:24Z
dc.date.issued2016
dc.identifier.citationhttp://www.eurekaselect.com/143508/article
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.urihttps://hdl.handle.net/10669/74733
dc.description.abstractThe snake is the symbol of medicine due to its association with Asclepius, the Greek God of medicine, and so with good reasons. More than 725 species of venomous snakes have toxins specifically evolved to exert potent bioactivity in prey or victims, and snakebites constitute a public health hazard of high impact in Asia, Africa, Latin America, and parts of Oceania. Parenteral administration of antivenoms is the mainstay in snakebite envenoming therapy. However, despite well-demonstrated efficacy and safety of many antivenoms worldwide, they are still being produced by traditional animal immunization procedures, and therefore present a number of drawbacks. Technological advances within biopharmaceutical development and medicinal chemistry could pave the way for rational drug design approaches against snake toxins. This could minimize the use of animals and bring forward more effective therapies for snakebite envenomings. In this review, current stateof- the-art in biopharmaceutical antitoxin development is presented together with an overview of available bioinformatics and structural data on snake venom toxins. This growing body of scientific and technological tools could define the basis for introducing a rational drug design approach into the field of snakebite envenoming therapy.es_ES
dc.language.isoen_USes_ES
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceCurrent Pharmaceutical Design, 22, 5270-5293es_ES
dc.subjectantivenenoses_ES
dc.subjectSnake venomes_ES
dc.titleFrom Fangs to Pharmacology: The Future of Snakebite Envenoming Therapyes_ES
dc.typeartículo original
dc.identifier.doi10.2174/1381612822666160623073438
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES
dc.identifier.pmid27339430


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CC0 1.0 Universal
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