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dc.creatorSanz, Libia
dc.creatorPla Ferrer, Davinia
dc.creatorPérez, Alicia
dc.creatorRodríguez, Yania
dc.creatorZavaleta Martínez Vargas, Alfonso
dc.creatorSalas Arruz, María
dc.creatorLomonte, Bruno
dc.creatorCalvete Chornet, Juan José
dc.date.accessioned2018-05-03T21:13:28Z
dc.date.available2018-05-03T21:13:28Z
dc.date.issued2016
dc.identifier.citationhttp://www.mdpi.com/2072-6651/8/6/178
dc.identifier.issn2072-6651
dc.identifier.otherTOXIB7
dc.identifier.urihttps://hdl.handle.net/10669/74607
dc.description.abstractThe venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms (~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert coral snake venom. Phospholipases A2 (PLA2s; seven isoforms, 4.1% of the venom proteome), 1–3 Kunitz-type proteins (1.6%), and 1–2 L-amino acid oxidases (LAO, 0.7%) complete the toxin arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent venom phenotypes, i.e., 3FTx- and PLA2-predominant venom proteomes, may constitute a general trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA2 dichotomy may be widely distributed among Elapidae venoms.es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad/[BFU2013-42833-P]/Mineco/Españaes_ES
dc.language.isoen_USes_ES
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceToxins, vol. 8 (6), 178.es_ES
dc.subjectMicruruses_ES
dc.subjectVenomes_ES
dc.subjectProteomees_ES
dc.subjectVenomicses_ES
dc.subjectThree-finger toxines_ES
dc.subjectSnake venom phospholipase A 2es_ES
dc.subjectMass spectrometryes_ES
dc.subjectMicrurus tschudii tschudiies_ES
dc.titleVenomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venomses_ES
dc.typeartículo científico
dc.identifier.doi10.3390/toxins8060178
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmidPMC4926144
dc.identifier.pmid27338473


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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal