Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms
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Date
2016Author
Sanz, Libia
Pla Ferrer, Davinia
Pérez, Alicia
Rodríguez, Yania
Zavaleta Martínez Vargas, Alfonso
Salas Arruz, María
Lomonte, Bruno
Calvete Chornet, Juan José
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The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii
was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake
venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms
(~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert
coral snake venom. Phospholipases A2 (PLA2s; seven isoforms, 4.1% of the venom proteome),
1–3 Kunitz-type proteins (1.6%), and 1–2 L-amino acid oxidases (LAO, 0.7%) complete the toxin
arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent
venom phenotypes, i.e., 3FTx- and PLA2-predominant venom proteomes, may constitute a general
trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic
variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA2 dichotomy
may be widely distributed among Elapidae venoms.
External link to the item
10.3390/toxins8060178Collections
- Microbiología [990]
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