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dc.creatorMora Gallegos, Andrea
dc.creatorRojas Carvajal, Mijail
dc.creatorSalas Castillo, Sofía
dc.creatorSaborío Arce, Adriana
dc.creatorFornaguera Trías, Jaime
dc.creatorBrenes Sáenz, Juan Carlos
dc.date.accessioned2018-02-19T14:14:10Z
dc.date.available2018-02-19T14:14:10Z
dc.date.issued2015
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S1074742714002093?via%3Dihub
dc.identifier.issn1074-7427
dc.identifier.urihttps://hdl.handle.net/10669/74107
dc.description.abstractAlthough aging and environmental stimulation are well-known to affect cognitive abilities, the question of whether aging effects can be distinguished in already-mature adult rats has not been fully addressed. In the present study, therefore, young and mature adult rats were housed in either enriched or standard conditions (EE or SC) for three months. Open-field (OFT) and radial-maze (RM) behavior, and ex-vivo contents of GABA and glutamate in hippocampus, and of dopamine and DOPAC in ventral striatum (VS) were analyzed and compared between the four groups. In OFT, young rats were more active than mature adults irrespective of the housing condition. Surprisingly, in the RM test, mature adults outperformed young counterparts except for the young-enriched rats, which showed a progressive improvement in RM performance. At the neurochemical level, young EE rats showed higher hippocampal glutamate and GABA concentrations, and DA turnover in VS, which correlated with RM performance. Altogether, the behavioral and cognitive strategies underlying habituation learning and spatial memory seem to be qualitatively different between the two ages analyzed. These results challenge the assumption that mature adult animals are always worse in learning and memory tasks. However, young rats benefited more from the social and physical stimulation provided by the enrichment than mature adult counterparts. The latter effect was evident not just on behavior, but also on brain neurochemistry.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[422-A9-602]/UCR/Costa Ricaes_ES
dc.description.sponsorshipConsejo Nacional para Investigaciones Científicas y Tecnológicas/[FI-302-09]/CONICIT/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceNeurobiology of Learning and Memory, Vol. 118, pp. 96-104.es_ES
dc.subjectAgees_ES
dc.subjectEnvironmental enrichmentes_ES
dc.subjectHabituationes_ES
dc.subjectSpatial learninges_ES
dc.subjectWorking, reference memoryes_ES
dc.subjectDopaminees_ES
dc.subjectGABAes_ES
dc.subjectGlutamatees_ES
dc.titleAge-dependent effects of environmental enrichment on spatial memory and neurochemistryes_ES
dc.typeartículo científico
dc.identifier.doi10.1016/j.nlm.2014.11.012
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP)es_ES
dc.identifier.codproyecto422-A9-602


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