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Association of Apolipoprotein E-e4 and Dementia Declines with Age
dc.creator | Valerio Aguilar, Daniel | |
dc.creator | Raventós Vorst, Henriette | |
dc.creator | Schmeidler, James | |
dc.creator | Beeri, Michal S. | |
dc.creator | Mora Villalobos, Lara | |
dc.creator | Bolaños Palmieri, Patricia | |
dc.creator | Carrión Baralt, José R. | |
dc.creator | Fornaguera Trías, Jaime | |
dc.creator | Silverman, Jeremy M. | |
dc.date.accessioned | 2018-01-23T15:13:31Z | |
dc.date.available | 2018-01-23T15:13:31Z | |
dc.date.issued | 2014-10 | |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/S1064748114001080?via%3Dihub#! | |
dc.identifier.issn | 1064-7481 | |
dc.identifier.uri | https://hdl.handle.net/10669/73972 | |
dc.description.abstract | To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years. Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact. The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[]/UCR/Costa Rica | es_ES |
dc.description.sponsorship | Fogarty International Center/[]/NIH/Estados Unidos | es_ES |
dc.description.sponsorship | National Institute on Aging/[R21TW009258]/NIH/Estados Unidos | es_ES |
dc.description.sponsorship | Alzheimer’s Association/[]//Estados Unidos | es_ES |
dc.language.iso | es | es_ES |
dc.source | The American Journal of Geriatric Psychiatry. Vol. 22 (10), pp. 957-960 | es_ES |
dc.subject | Successful cognitive aging | es_ES |
dc.subject | Oldest-old | es_ES |
dc.subject | Dementia risk factors | es_ES |
dc.title | Association of Apolipoprotein E-e4 and Dementia Declines with Age | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1016/j.jagp.2014.03.008 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicina | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biología | es_ES |