Molecular Characterization of Two Major Dengue Outbreaks in Costa Rica
artículo original
Fecha
2016-07Autor
Soto Garita, Claudio
Somogyi Pérez, Teresa
Vicente Santos, Amanda
Corrales Aguilar, Eugenia
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Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne virus with a worldwide
circulation, transmitted mainly by Aedes aegypti and Aedes albopictus mosquitoes. Since the first detection of its main
transmitting vector in 1992 and the invasion of DENV-1 in 1993, Costa Rica has faced dengue outbreaks yearly. In
2007 and 2013, Costa Rica experienced two of the largest outbreaks in terms of total and severe cases. To provide
genetic information about the etiologic agents producing these outbreaks, we conducted phylogenetic analysis of viruses
isolated from human samples. A total of 23 DENV-1 and DENV-2 sequences were characterized. These analyses signaled
that DENV-1 genotype V and DENV-2 American/Asian genotype were circulating in those outbreaks. Our results suggest
that the 2007 and 2013 outbreak viral strains of DENV-1 and DENV-2 originated from nearby countries and
underwent in situ microevolution.
External link to the item
https://doi.org/10.4269/ajtmh.15-0835Colecciones
- Microbiología [1171]