Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms
artículo original
View/ Open
Date
2013-12-15Author
León Montero, Guillermo
Herrera Vega, María
Segura Ruiz, Álvaro
Villalta Arrieta, Mauren
Vargas Arroyo, Mariángela
Gutiérrez, José María
Metadata
Show full item recordAbstract
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their therapeutic success lies in their ability to mitigate the progress of toxic effects induced by snake venom components, when administered intravenously. However, due to diverse factors, such as deficient manufacturing practices, physicochemical characteristics of formulations, or inherent properties of heterologous immunoglobulins, antivenoms can induce undesirable adverse reactions. Based on the time lapse between antivenom administration and the onset of clinical manifestations, the World Health Organization has classified these adverse reactions as: 1 – Early reactions, if they occur within the first hours after antivenom infusion, or 2 – late reactions, when occurring between 5 and 20 days after treatment. While all late reactions are mediated by IgM or IgG antibodies raised in the patient against antivenom proteins, and the consequent formation of immune complexes, several mechanisms may be responsible for the early reactions, such as pyrogenic reactions, IgE-mediated reactions, or non IgE-mediated reactions. This work reviews the hypotheses that have been proposed to explain the mechanisms involved in these adverse reactions to antivenoms. The understanding of these pathogenic mechanisms is necessary for the development of safer products and for the improvement of snakebite envenomation treatment.
External link to the item
10.1016/j.toxicon.2013.09.010Collections
- Microbiología [1171]
Related items
Showing items related by title, author, creator and subject.
-
Synthesis of 2-hydroxy-3-substituted naphthoquinones using the Heck reaction
Pérez Sánchez, Alice Lorena; Lamoureux Lamontagne, Guy; Zhen-Wu, Bi Yun (2007-06)An efficient Heck coupling of 2-hydroxy-3-iodo-naphthoquinone with a series of electron-deficient alkenes in aqueous solution has been accomplished. The method is characterized by simple conditions and facile work-up to ... -
Farmacovigilancia en Costa Rica; la percepción del personal médico
González Argüello, Ronald (2007-06-01)La farmacovigilancia es el estudio de los daños relacionados a los medicamentos con el propósito de realizar advertencias o recomendaciones de retiro de productos farmacéuticos. Hasta ahora no existen datos sobre la ... -
Well-posedness and discrete analysis for advection-diffusion-reaction in poroelastic media
Verma, Nitesh; Gómez Vargas, Bryan Andrés; De Oliveira Vilaca, Luis Miguel; Kumar, Sarvesh; Ruiz Baier, Ricardo (2021)We analyse a PDE system modelling poromechanical processes (formulated in mixed form using the solid deformation, fluid pressure, and total pressure) interacting with diffusing and reacting solutes in the medium. We ...