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dc.creatorLomonte, Bruno
dc.creatorTsai, Wan-Chih
dc.creatorBonilla Murillo, Fabián
dc.creatorSolórzano López, Alejandro
dc.creatorSolano Trejos, María Gabriela
dc.creatorAngulo Ugalde, Yamileth
dc.creatorGutiérrez, José María
dc.creatorCalvete Chornet, Juan José
dc.date.accessioned2017-03-24T19:35:43Z
dc.date.available2017-03-24T19:35:43Z
dc.date.issued2012-04
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010112000232
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29617
dc.description2082/04 Embargo por política editoriales_ES
dc.description.abstractThe genus Bothriechis comprises a lineage of nine species of Neotropical pitvipers distributed mainly in highlands across Middle America, all adapted to arboreal habitats. Bothriechis supraciliaris is a relatively recently described species that inhabits the Pacific southwest of Costa Rica, whose venom had never been studied. A proteomic and toxicological profiling of its venom is here reported. Proteins or peptides that belong to eleven families were found, with a predominance of bradykinin-potentiating peptides (21.9%), followed by serine proteinases (15.2%) and phospholipases A2 (13.4%). A group of short polyglycine peptides, resembling the poly-His/poly-Gly metalloproteinase inhibitors described in Atheris and Echis snake venoms, was observed for the first time in a Bothriechis venom. Comparison of the venom proteome of B. supraciliaris with those of Bothriechis schlegelii, Bothriechis lateralis, and Bothriechis nigroviridis, confirms the highly diverse toxicological strategies evolved by these arboreal snakes in each case, as possible alternative solutions to the same trophic purpose. Toxicological profiling of B. supraciliaris venom revealed a potent hemorrhagic action, moderate myotoxicity, and very weak procoagulant activity. Importantly from the medical perspective, the lethal activity of its venom (mouse intraperitoneal LD50: 7.1 μg/g) was efficiently neutralized by a polyvalent (Viperidae) antivenom of therapeutic use in Central America.es_ES
dc.description.sponsorshipMinisterio de Ciencia y Tecnología/[108-2011]/MICITT/Costa Ricaes_ES
dc.description.sponsorshipConsejo Nacional para Investigaciones Científicas y Tecnológicas/[108-2011]/CONICIT/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B1-549]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Innovación y Ciencia/[BFU2010-17373]//Españaes_ES
dc.description.sponsorshipGeneralitat Valenciana/[PROMETEO/2010/005]//Españaes_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas/[2009CR0021]/CRUSA-CSIC/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 59, Número 5. 2012es_ES
dc.subjectSnake venomes_ES
dc.subjectViperidaees_ES
dc.subjectProteomicses_ES
dc.subjectVenomicses_ES
dc.subjectMass spectrometryes_ES
dc.subjectArboreales_ES
dc.subjectBothriechis supraciliarises_ES
dc.titleSnake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Ricaes_ES
dc.typeartículo científico
dc.identifier.doi10.1016/j.toxicon.2012.01.005
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid22333435


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