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dc.creatorRucavado Romero, Alexandra
dc.creatorEscalante Muñoz, Teresa
dc.creatorFranceschi, Aida
dc.creatorChaves Mora, Fernando
dc.creatorLeón Montero, Guillermo
dc.creatorCury, Yara
dc.creatorOvadia, Michael
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-30T21:40:18Z
dc.date.available2017-01-30T21:40:18Z
dc.date.issued2000-11
dc.identifier.citationhttp://www.ajtmh.org/content/63/5/313.long
dc.identifier.issn0002-9637
dc.identifier.urihttps://hdl.handle.net/10669/29472
dc.description.abstractThe effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice. Both compounds totally inhibited proteolytic, hemorrhagic, and dermonecrotic effects, and partially reduced edema-forming activity, when incubated with venom prior to injection. Much lower concentrations of batimastat than of CaNa2EDTA were required to inhibit these effects. In addition, batimastat, but not CaNa2EDTA, partially reduced myotoxic activity of the venom. When the inhibitors were administered at various time intervals after envenomation at the same site of venom injection, both compounds were effective in neutralizing local hemorrhage and dermonecrosis if administered rapidly after venom. Inhibition was not as effective as the time lapse between venom and inhibitor injections increased. Owing to the relevance of metalloproteinases in the pathogenesis of local tissue damage induced by B. asper and other pit viper venoms, it is suggested that administration of peptidomimetic metalloproteinase inhibitors or CaNa2EDTA at the site of venom injection may represent a useful alternative to complement antivenoms in the neutralization of venom-induced local tissue damage.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-98-202]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-99-220]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science/[F/2707-1]/IFS/Sueciaes_ES
dc.language.isoen_USes_ES
dc.sourceThe American Journal of Tropical Medicine and Hygiene; Volumen 63, Número 5. 2000es_ES
dc.subjectAnimalses_ES
dc.subjectBothropses_ES
dc.subjectChelating Agentses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectDisease Models, Animales_ES
dc.subjectEdetic Acides_ES
dc.subjectHemorrhagees_ES
dc.subjectInjections, Intralesionales_ES
dc.subjectMatrix Metalloproteinase Inhibitorses_ES
dc.subjectMicees_ES
dc.subjectNecrosises_ES
dc.subjectPhenylalaninees_ES
dc.subjectSnake Biteses_ES
dc.subjectThiopheneses_ES
dc.subjectSnake venomes_ES
dc.titleInhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTAes_ES
dc.typeartículo científico
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-98-202
dc.identifier.pmid11421384


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