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dc.creatorBogarín, Guisella
dc.creatorRomero, Marjorie
dc.creatorRojas Céspedes, Gustavo
dc.creatorLutsch, Charles
dc.creatorCasadamont, Michel
dc.creatorLang, Jean
dc.creatorOtero Patiño, Rafael
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-23T16:29:57Z
dc.date.available2017-01-23T16:29:57Z
dc.date.issued1999-03
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010198001937es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29450
dc.description.abstractA monospecific Bothrops lanceolatus antivenom, currently used in Martinique, was tested for its efficacy in the neutralization of several toxic and enzymatic activities of the venoms of B. lanceolatus, B. atrox and B. asper. When tested by the i.p. route in mice, B. lanceolatus venom had an LD50 of 12.8 microg/g. In addition, it induced local tissue damage (hemorrhage, edema and myotoxicity) and showed indirect hemolytic activity, but was devoid of coagulant effect on human plasma in vitro and of defibrinating activity in mice. Antivenom was fully effective in the neutralization of lethal, hemorrhagic, edema-forming, myotoxic and indirect hemolytic effects of B. lanceolatus venom in assays involving preincubation of venom and antivenom. When tested against the venoms of B. asper and B. atrox, the antivenom completely neutralized the lethal, hemorrhagic, myotoxic and indirect hemolytic effects, and was partially effective in neutralizing edema-forming activity. In contrast, the antivenom was ineffective in the neutralization of in vitro coagulant and in vivo defibrinating effects induced by these two venoms.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-89-057]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 37, Número 3, 1999es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectBothropses_ES
dc.subjectHumanses_ES
dc.subjectIn Vitro Techniqueses_ES
dc.subjectMicees_ES
dc.subjectSnake venomes_ES
dc.titleNeutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothı́rops snake venomses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(98)00193-7
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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