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dc.creatorChaves Mora, Fernando
dc.creatorLeón, Georgina
dc.creatorAlvarado, Victor Hugo
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-18T21:19:02Z
dc.date.available2017-01-18T21:19:02Z
dc.date.issued1998-12
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S004101019800107Xes_ES
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29441
dc.description.abstractThe pharmacological modulation of edema-forming activity of Bothrops asper myotoxins II and III, Lys-49 and Asp-49 phospholipases A2, respectively, was studied plethysmographically in the mouse foot pad model. Myotoxin III had phospholipase A2 activity, whereas myotoxin II was devoid of enzymatic activity when tested on egg yolk phosphatidylcholine. Both toxins induced a dose-dependent edema of rapid onset. Chemical modification of myotoxin III with p-bromophenacyl bromide abrogated enzymatic activity and significantly reduced edemat-forming activity, although a residual effect remained. Pre-treatment of animals with diphenhydramine, dexamethasone, indomethacin and prazosin significantly reduced the effect of both myotoxins. It is concluded that (a) these myotoxins are important edema-forming components of B. asper venom, (b) enzymatic activity is not a strict requirement to exert this effect, although in the case of myotoxin III it contributes to its development, and (c) several inflammatory mediators participate in mouse foot pad edema induced by these myotoxins.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-90-038]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 36, Número 12, 1998es_ES
dc.subjectAnimalses_ES
dc.subjectAnti-Inflammatory Agentses_ES
dc.subjectBothropses_ES
dc.subjectDexamethasonees_ES
dc.subjectDiphenhydraminees_ES
dc.subjectDose-Response Relationship, Druges_ES
dc.subjectEdemaes_ES
dc.subjectFootes_ES
dc.subjectIndomethacines_ES
dc.subjectMicees_ES
dc.subjectMuscle, Skeletales_ES
dc.subjectPhospholipases Aes_ES
dc.subjectPhospholipases A2es_ES
dc.subjectPlethysmographyes_ES
dc.subjectPrazosines_ES
dc.subjectTime Factorses_ES
dc.subjectSnake venomes_ES
dc.titlePharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo)es_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(98)00107-X
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-90-038


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