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dc.creatorGallagher, Paul
dc.creatorBao, Yongde
dc.creatorSerrano, Solange M. T.
dc.creatorLaing, Gavin D.
dc.creatorTheakston, R. David G.
dc.creatorGutiérrez, José María
dc.creatorEscalante Muñoz, Teresa
dc.creatorZigrino, Paola
dc.creatorMoura Da Silva, Ana M.
dc.creatorNischt, Roswitha
dc.creatorMauch, Cornelia
dc.creatorMoskaluk, Christopher
dc.creatorFox, Jay W.
dc.date.accessioned2017-01-18T14:48:08Z
dc.date.available2017-01-18T14:48:08Z
dc.date.issued2005-09
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0003986105002407
dc.identifier.issn0003-9861
dc.identifier.urihttps://hdl.handle.net/10669/29432
dc.description.abstractTo assess the indirect effects of snake venom metalloproteinases (SVMP) on host tissue local necrosis, we investigated the effect of the SVMP jararhagin on the gene expression profiles of human fibroblasts in vitro and mouse tissue in vivo. Two functional classes of up-regulated proteins, cell death and inflammatory disease were identified as being significantly populated. The changes in gene expression observed by qRT-PCR on laser microdissected mouse muscle tissue treated with jararhagin were similar with significant up-regulation of proinflammatory transcripts such as IL-1β, IL-6, CXCL1, CXCL2, IL-8, and apoptosis, inflammation responsive transcripts such as TNF-α induced protein 6. Proteolytically inactive jararhagin had no effect on the gene expression profile of fibroblasts, indicating proteolysis as the primary mechanism affecting gene expression of cells and tissues resulting in a proinflammatory, pro-apoptotic host response which likely exacerbates the local necrosis frequently observed at the site of envenoming.es_ES
dc.description.sponsorshipUniversity of Cologne/[10/2004]//Alemaniaes_ES
dc.description.sponsorshipUniversity of Cologne/[SFB 589]//Alemaniaes_ES
dc.language.isoen_USes_ES
dc.sourceArchives of Biochemistry and Biophysics; Volumen 441, Número 1. 2005es_ES
dc.subjectInflammationes_ES
dc.subjectApoptosises_ES
dc.subjectAnoikises_ES
dc.subjectGene Expressiones_ES
dc.subjectSnake venomes_ES
dc.subjectMetalloproteinaseses_ES
dc.titleRole of the snake venom toxin jararhagin in proinflammatory pathogenesis: In vitro and in vivo gene expression analysis of the effects of the toxines_ES
dc.typeartículo científico
dc.identifier.doi10.1016/j.abb.2005.06.007
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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