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dc.creatorOlivo, Renata do A.
dc.creatorTeixeira, Catarina de Fátima
dc.creatorWallace, John L.
dc.creatorGutiérrez, José María
dc.creatorZamunér, Stella Regina
dc.date.accessioned2016-12-09T19:49:41Z
dc.date.available2016-12-09T19:49:41Z
dc.date.issued2007-04
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010106004235
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29384
dc.description.abstractThe venoms of Bothrops asper (BaV) and Bothrops jararaca (BjV), two of the most medically important poisonous snakes of Latin America, cause pronounced oedema in the victims through poorly understood mechanisms. In the present study, we examined the possible role of cyclooxygenases (COX) in the genesis of mouse paw oedema caused by BaV and BjV injections. BaV at 2.5 μg/paw and BjV at 0.75 μg/paw induced significant oedema that persisted for up to 6 h following subplantar injection. Treatment with indomethacin (2 mg/kg), rofecoxib, (10 mg/kg), or dexamethasone (2 mg/kg) significantly reduced the BaV- and BjV-induced oedema formation. Treatment with SC-560 (30 mg/kg) significantly reduced the oedema formation induced by BjV but had no effect on that induced by BaV. Both venoms induced significant increases in the levels of prostaglandin E2 (PGE2) and the expression of COX-1 and COX-2 in paw tissue. The peak of oedema formation and PGE2 release correlated with marked expression of COX-2 in the paw tissue. These results demonstrate that injection of BaV and BjV results in a rapid increase in oedema formation that is, at least partially, mediated by arachidonic acid metabolites formed by COX-2. In the case of BjV, COX-1-derived prostanoids also appear to contribute significantly to the inflammatory changes.es_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[02/13863-2]/FAPESP/Brasiles_ES
dc.description.sponsorshipCanadian Institutes of Health Research//CIHR/Canadáes_ES
dc.description.sponsorshipJanssen Pharmaceutica and the Canadian Association of Gastroenterology///Canadáes_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[98/0162-9]/FAPESP/Brasiles_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[02/10861-9]/FAPESP/Brasiles_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 49, Número 5. 2007es_ES
dc.subjectBothrops Asperes_ES
dc.subjectBothrops Jararacaes_ES
dc.subjectCyclooxygenasees_ES
dc.subjectInflammationes_ES
dc.subjectCOX-2es_ES
dc.subjectPGE2es_ES
dc.subjectSnake venomes_ES
dc.titleRole of cyclooxygenases in oedema-forming activity of bothropic venomses_ES
dc.typeartículo original
dc.identifier.doi10.1016/j.toxicon.2006.11.006
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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