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dc.creatorGutiérrez, José María
dc.creatorRucavado Romero, Alexandra
dc.creatorEscalante Muñoz, Teresa
dc.creatorLomonte, Bruno
dc.creatorAngulo Ugalde, Yamileth
dc.creatorFox, Jay W.
dc.date.accessioned2016-11-29T14:33:19Z
dc.date.available2016-11-29T14:33:19Z
dc.date.issued2010-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010109004267
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29332
dc.description.abstractThe study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental observations, however, indicate that cells and extracellular matrix are affected by venoms and toxins in a complex and heterogeneous fashion, and that the effect of whole venoms in whole organisms cannot be properly assessed by studying only the action of isolated toxins in isolated systems. It is proposed that a novel conceptual and methodological frame is necessary to better understand the complexity of these pathological alterations from a holistic, systems biology perspective.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 55, Número 1. 2010es_ES
dc.subjectPathologyes_ES
dc.subjectSnake venomes_ES
dc.subjectSystems biologyes_ES
dc.titleTissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?es_ES
dc.typeartículo original
dc.identifier.doi10.1016/j.toxicon.2009.08.006
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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