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dc.creatorEstrada Umaña, Ricardo
dc.creatorHerrera Vega, María
dc.creatorSegura Ruiz, Álvaro
dc.creatorAraya, Javier
dc.creatorBoschini Figueroa, Carlos
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2016-11-28T19:28:30Z
dc.date.available2016-11-28T19:28:30Z
dc.date.issued2010-11
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S1045105610001569
dc.identifier.issn1045-1056
dc.identifier.urihttps://hdl.handle.net/10669/29322
dc.description.abstractAdministration of antivenoms to treat snakebite envenomings has the potential risk of inducing early adverse reactions. The mechanisms involved in these reactions are unclear. In this study, polyspecific antivenom consisting of whole IgG purified from equine plasma by caprylic acid precipitation was administered intravenously to non-envenomed horses (n = 47) and cows (n = 20) at a dose of 0.4 mL/kg. It has been reported that, in humans, this formulation (administered at a dose of 0.4 mL/kg) induces mild noticeable early adverse reactions, such as fever, vomiting, diarrhea, urticaria, generalized rash, tachypnea or tachycardia, in about 15–20% of the patients. Unexpectedly, none of the animals receiving antivenom in our study showed any evidence of early adverse reaction. Moreover, no late adverse reactions, i.e. serum sickness, were observed during 40 days after antivenom administration. Unlike studies performed in envenomed humans, our present results were obtained in a group of non-envenomed individuals. It is concluded that, in addition to the physicochemical characteristics of the formulation, other unknown factors must determine the occurrence of adverse reactions in snakebite envenomed humans treated with equine-derived antivenoms.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnología para el Desarrollo/[206AC0281]/CYTED/Españaes_ES
dc.language.isoen_USes_ES
dc.sourceBiologicals; Volumen 38, Número 6. 2010es_ES
dc.subjectSnake Bitees_ES
dc.subjectAntivenomes_ES
dc.subjectEarly adverse reactionses_ES
dc.subjectCaprylic acides_ES
dc.subjectCowes_ES
dc.subjectHorsees_ES
dc.subjectSnake venomes_ES
dc.titleIntravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cowses_ES
dc.typeartículo original
dc.identifier.doi10.1016/j.biologicals.2010.08.002
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Estación Experimental de Ganado Lechero Alfredo Volio Mata (EEAVM)es_ES


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