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dc.creatorEstrada Umaña, Ricardo
dc.creatorGutiérrez, José María
dc.creatorAlvarado, Jorge
dc.creatorRobles, Abel
dc.creatorÁvila Agüero, Claudio
dc.creatorGonzález, Nuria
dc.date.accessioned2016-11-21T01:54:06Z
dc.date.available2016-11-21T01:54:06Z
dc.date.issued1989
dc.identifier.issn2215-2075
dc.identifier.urihttps://hdl.handle.net/10669/29272
dc.description.abstractThe development of antibody response against phospholipase A activity of Bothrops asper venom was studied in a group of adult and healthy horses used in the production ofthe polyvalent antivenom at the Instituto Clodomiro Picado. Simultaneously, the general condition of the animals during the immunization schedule was also studied. There was a great individual variability in me ¡mmune response, although most of the horses studied reached the highest neutralizing titer aftrr injection of doses of venom of 30 mg and 50 mg. On the other hand, in horses that had been previously imnmunized and were injected for a second immunization, the highest antibody titer was observed 16-22 days after inoculation. There were only mild alterations in the general condtion of the horses as a consequence of venom inoculation. However, local abscesses, fistules and fibrosis were observed at the site of venom injection. On the basis of the conspicuous individual variability observed, it is proposed that the immune response in horses used in the production of antivenom must be evaluated on individual basis, instead of working with pools of serum samples.es_ES
dc.language.isoeses_ES
dc.sourceRevista de Biología Tropical; Volumen 37, Número 2, 1989es_ES
dc.subjectBothropses_ES
dc.subjectCrotaluses_ES
dc.subjectLachesises_ES
dc.subjectAntibodieses_ES
dc.subjectAntivenomes_ES
dc.subjectAnti-phospholipase antiofídicoes_ES
dc.subjectAnti-fosfolipasaes_ES
dc.titleDesarrollo de la respuesta de anticuerpos anti-fosfolipasa A, en caballos inoculados con veneno para la producción de suero antiofídico polivalente en Costa Ricaes_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.15517/rbt.v37i2.23584
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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