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dc.creatorMoreira Carmona, Lisela
dc.creatorBorkow, Gadi
dc.creatorOvadia, Michael
dc.creatorGutiérrez, José María
dc.date.accessioned2016-11-11T14:50:49Z
dc.date.available2016-11-11T14:50:49Z
dc.date.issued1994-08
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29230
dc.description.abstractThe pathological changes induced in capillaries by BaH1, a hemorrhagic metalloproteinase isolated from the venom of Bothrops asper, were studied after i.m. injection in mouse gastrocnemius. Hemorrhage was observed macroscopically, and corroborated histologically, within the first 5 min. At the ultrastructural level, the earliest changes in endothelial cells, observed 1 min after toxin administration, consisted of a decrease in the number of pinocytotic vesicles, the presence of blebs and cytoplasmic projections pinching off to the vascular lumen and the detachment of endothelial cells from the surrounding basal lamina. These processes occurred concomitantly with a thinning of endothelial cells. In capillaries undergoing more advanced degenerative stages, there were gaps or breaks in endothelial cells through which erythrocytes were escaping to the extravascular space. In these cells, the basal lamina was usually absent. Throughout this process, intercellular junctions remained apparently intact and no evidence was found of extravasation through widened intercellular junctions. In addition to this morphological pattern of degeneration, some capillaries presented swollen endothelial cells with dilated endoplasmic reticulum and lacking pinocytotic vesicles. Many capillaries contained platelet plugs and fibrin. Thus, hemorrhage induced by BaH1 occurs per rhexis, as has been also described for other venoms and hemorrhagic toxins.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 32, Número 8, 1994es_ES
dc.subjectAnimalses_ES
dc.subjectBasement Membranees_ES
dc.subjectBothropses_ES
dc.subjectCapillarieses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectElectrophoresis, Polyacrylamide Geles_ES
dc.subjectEndopeptidaseses_ES
dc.subjectEndoplasmic Reticulumes_ES
dc.subjectEndothelium, Vasculares_ES
dc.subjectHemorrhagees_ES
dc.subjectInjections, Intramusculares_ES
dc.subjectIntercellular Junctionses_ES
dc.subjectIsoelectric Focusinges_ES
dc.subjectMetalloendopeptidaseses_ES
dc.subjectMicees_ES
dc.subjectMicroscopy, Electrones_ES
dc.subjectMuscle, Skeletales_ES
dc.subjectSnake venomes_ES
dc.titlePathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vesselses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(94)90376-X
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es_ES


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