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dc.creatorGutiérrez, José María
dc.creatorRojas Céspedes, Gustavo
dc.creatorPérez, A.
dc.creatorArguello, I.
dc.creatorLomonte, Bruno
dc.date.accessioned2016-11-09T21:39:29Z
dc.date.available2016-11-09T21:39:29Z
dc.date.issued1991
dc.identifier.citationhttps://www.ncbi.nlm.nih.gov/pubmed/1823287es_ES
dc.identifier.issn0100-879X
dc.identifier.urihttps://hdl.handle.net/10669/29167
dc.description.abstractThe neutralizing ability of a monovalent anti-Micrurus nigrocinctus (coral snake) antivenom produced in Costa Rica was tested against the lethal, myotoxic and phospholipase A2 activities of homologous venom. In addition, immunodiffusion and Western blot analyses were performed. 2. In experiments where venom and antivenom were incubated prior to the test, antivenom was effective in neutralizing lethal, myotoxic and phospholipase A2 activities, with Effective Doses 50% of 2700 microliters antivenom/mg venom, 1840 microliters antivenom/mg venom, and 3630 microliters antivenom/mg venom, respectively. 3. When coral snake antivenom was administered at different times after coral snake venom injection, neutralization of lethality was achieved when antivenom was injected i.v. immediately and 15 min after venom. In contrast, lethality was not reduced when antivenom was administered by the im route. Only partial neutralization of myotoxicity was observed even when antivenom was injected i.v. immediately after envenomation. 4. Immunodiffusion and immunoblot analyses demonstrated the presence of antibodies in antivenom against several, but not all, venom components.es_ES
dc.language.isoen_USes_ES
dc.sourceBrazilian journal of medical and biological research. Volumen 24, Número 7, 1991es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectBlotting, Westernes_ES
dc.subjectElapid Venomses_ES
dc.subjectImmunodiffusiones_ES
dc.subjectLethal Dose 50es_ES
dc.subjectMicees_ES
dc.subjectPhospholipases Aes_ES
dc.subjectPhospholipases A2es_ES
dc.subjectSpecies Specificityes_ES
dc.subjectSnake venomes_ES
dc.titleNeutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenomes_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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