Química
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Synthesis and preliminary determination of antibacterial activity of some 1,3-enynes
(2019)The synthesis of five 1,3-enynes was performed and its activity against Gram-positive and Gram-negative bacteria was determined. -
Antimicrobial activity of sodium carboxylates against arcobacter sp. y campylobacter Sp.
(2019)Arcobacter and Campylobacter genres are pathogenic microorganisms associated with gastrointestinal diseases and their main transmission route is through food and water. Both genres have been strongly associated to poultry, ... -
5,5-Diphenyl-cis-penta-2,4-dienoic acid
(2019)In the title compound, C17H14O2, the dihedral angle between the phenyl rings is 76.52 (7)°. In the crystal, pairwise O—H⋯O hydrogen bonds link the molecules into carboxylic acid inversion dimers. -
N-[3-(Prop-1-yn-1-yl)phenyl]benzenesulfonamide
(2019)In the title sulfanilamide derivative, C15H13NO2S, which shows significant activity against Staphylococcus aureus and Escherichia coli, the dihedral angle between the planes of the aromatic rings is 62.15 (19)° and the ... -
A Facile Method for the Titration of Organolithium Reagents using Naphtylamine or Naphtylmethylamine as Indicators
(2019)A simple method for the titration of alkyllithiums with sec-butanol, using naphtylamine or naphtylmethylamine as color indicator, is reported. Both amines gave sharp-end points, easily determined by color changes from ... -
One-Pot Conversion of Aldehydes and Ketones into 1-Substituted and 1,4-Disubstituted 1,3-Enynes
(2018)Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generates the operational equivalent of 1,3-dilithiopropyne, which upon treatment with aldehydes or ketones, produces the corresponding alkoxy lithium ... -
Synthesis and Biological Activity of New Antifungal Compounds: A Preliminary Study
(2018)In the present study, we synthesized three 1,3-enynes from their corresponding aldehydes. They exhibited antifungal activity, which was evaluated against Trichophyton rubrum, the most common dermatophyte responsible for ... -
A facile method for the preparation of bishomopropargylic alcohols from acyl chlorides
(2014)Controlled dilithiation of propargyl bromide with two equivalents of n-butyllithium, in the presence of TMEDA, produces the operational equivalent of the dianion 1,3-dilithiopropyne. The latter reacts efficiently with ... -
Nueva síntesis de la feromona sexual de la polilla del repollo Plutella Xylostella
(2007)El compuesto (Z)-11-hexadecenal, feromona sexual de la polilla Plutella xylostella, fue preparado mediante tres secuencias sintéticas. La primer secuencia consistió de siete pasos y un rendimiento total de 47%. En las otras ... -
Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs
(2018)Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural ... -
Nuevos métodos de preparación del 1,3-Dilitiopropino y sus aplicaciones en la síntesis de compuestos bioactivos
(2006)Se desarrolló un método para la preparación del 1,3-dilitiopropino, a partir de bromuro de propargilo. Este procedimiento ha sido usado para desarrollar nuevos métodos de síntesis de alcoholes homopropargílicos, 1,5-diinos, ... -
Stereospecific Synthesis of (E, Z)- and (Z, Z)-Hexadeca-10,12-dienal. Sex Pheromone Components of Diaphania hyalinata
(1998)Isomeric (E,Z)- and (Z,Z)-hexadeca-10,12-dienal were prepared, stereospecifically, in 51% and 43% overall yields from dec-1-yne. -
Propargylation of Carbonyl Compounds: An Efficient Method for the Synthesis of Homopropargyl Alcohols
(1998)Controlled dilithiation of allene, with two equivalents of n-butytlithium, produces the propargyl dianion 5. The latter couple efficiently with carbonyl compounds to produce homopropargyl alcohols in high yields. -
Antimicrobial activity of different sodium and potassium salts of carboxylic acid against some common foodborne pathogens and spoilage-associated bacteria
(2018)Cleaning and disinfection represent the most important activities associated with the elimination of dirt and microorganisms at food processing plants. Improper procedures may lead to cross contamination of food leading ... -
Fungi with history: Unveiling the mycobiota of historic documents of Costa Rica
(2022-06-12)Through nondestructive techniques, we studied the physicochemical characteristics and mycobiota of five key historic documents from Costa Rica, including the Independence Act of Costa Rica from 1821. We determined that for ... -
Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols
(2017)Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols ... -
Palladium-Catalyzed One-Pot Conversion of Aldehydes and Ketones into 4‑Substituted Homopropargyl Alcohols and 5‑En-3-yn-1-ols
(2017)Sequential treatment of 2,3-dichloropropene with magnesium and n-BuLi generated the equivalent of 1,3- dilithiopropyne, which adds regiospecifically to aldehydes and ketones to produce homopropargyl alcohols. The ... -
Synthesis and Determination of Antibacterial Activity of Jacaranone and Synthetic Analogs
(2017)Natural product jacaranone, 1, and five more analog derivatives were synthesized and its antibacterial activity against Gram-positive and Gram-negative microorganisms was tested. One of these derivatives, 5, ... -
Uncovering the Cultivable Microbial Diversity of Costa Rican Beetles and Its Ability to Break Down Plant Cell Wall Components
(2014)Coleopterans are the most diverse insect order described to date. These organisms have acquired an array of survival mechanisms through their evolution, including highly efficient digestive systems. Therefore, the coleopteran ... -
Identification of Protein Kinase C Activation as a Novel Mechanism for RGS2 Protein Upregulation through Phenotypic Screening of Natural Product Extracts
(2014)Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In ...
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