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(1S,3R)-N-{(3S,10S,12S,13R,17R)-12-Hydroxy-17- [(R)-5-hydroxypentan-2-yl]-10,13-dimethylhexa- decahydro-1H-cyclopenta[a]phenanthren-3-yl}- adamantane-1-carboxamide 0.25-hydrate
(2022-10-12)
The title compound, C 35H 57 NO 3 0.25H 2O, was synthesized from deoxycholic
acid followed by a protection, a Mitsonobu substitution, a Staudinger reduction,
formation of an amide and final reduction in the lateral chain. ...
Electrochemical biosensor for quantitative determination of fentanyl based on immobilized cytochrome c on multi-walled carbon nanotubes modified screen-printed carbon electrodes
(2022)
Fentanyl is a powerful synthetic opioid used to treat severe pain. New administration routes toward its illegal consumption
for recreational purposes pose a growing threat to public health, either due to misuse or abuse ...
Alkaloid contents in members of Lycopodiales
(2001)
The composition of alkaloids in fifteen species that belong to the Lycopodiales, which grow wild in Costa Rica were analysed by gas chromatography coupled with mass spectrometry. Several alkaloids were identified, ...
Tetraaquabis(2,3-dihydro-1,4-benzodioxine-2-carboxylato)calcium(II)
(2020)
The acid–base reaction of 1,4-benzodioxane 2-carboxylic acid with calcium carbonate furnished the centrosymmetric title compound, [Ca(C9H7O4)2(H2O)4], in which the metal ion is octahedrally coordinated by two monodentate ...
Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis
(2014)
Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus ...
Operando tracking of oxidation-state changes by coupling electrochemistry with time-resolved X-ray absorption spectroscopy demonstrated for water oxidation by a cobalt-based catalysts film
(2021)
Transition metal oxides are promising electrocatalysts for water oxidation, i.e., the oxygen evolution reaction (OER), which is
critical in electrochemical production of non-fossil fuels. The involvement of oxidation state ...
Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
(2019)
Bioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing ...
Adipostatins E-J, new potent antimicrobials identified as inhibitors of coenzyme-A biosynthesis
(2020-01)
Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ...
Experimental and theoretical studies of C–H⋯M interactions in palladium and platinum complexes derived from 1,2-bis-(2-hydroxymethylphenylthio)ethane
(2015-02)
The molecular structures of several related cis-[j2-SS-(L)MHal2] compounds 1, 1DMSO, 2, 2H2O,
3DMSO, 4 and 5 where L = HOCH2Ph-S-CH2-CH2-S-PhCH2OH, M = Pd or Pt, and Hal = Cl or Br or I, were analyzed by single crystal ...
Biodiversity Prospecting: The INBio Experience
(2004)
Bioprospecting is defined as the systematic search for genes, compounds, designs, and organisms that might have a potential economic use and might lead to a product development. In 1991, Costa Rica's National Institute of ...