A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in ...

High speed countercurrent chromatography (HSCCC) was used in a pre-fractionation pilot study to improve the quality of crude plant samples for primary screening in drug discovery efforts. The methanol ...

Alphaviruses are a prominent class of reemergent pathogens due to their globally expanding ranges, potential for lethality, and possible use as bioweapons. The absence of effective treatments for alphaviruses highlights ...

Se describen los métodos empleados en el estudio del efecto de extractos de insectos preparados en el Instituto Nacional de Biodiversidad de Costa Rica, sobre un tipo de malaria murina producida por el Plasmodium bergheim. ...

The aerial parts of Fleischmannia microstemon afforded in addition to sesamin and two clerodanes, ent-manoyl oxide and two derivatives of the latter, one a 6β-acetoxy derivative and the other a seco-labdane. From F. pratensis ...

Although there have been recent notable successes in thediscovery of ligands that target stable, high-affinity protein-protein interactions (PPIs), the transient and moderateaffinity PPIs that underpin many fundamental ...

A re-investigation of Calea prunifolia afforded, in addition to compounds reported previously, a new eudesmanolide, a costol acetate hydroperoxide and four aromatic compounds. Calea peckii gave a large variety of aromatic ...

Recombinant DNA technologies enable the direct isolation and expression of novel genes from biotopes containing complex consortia of uncultured microorganisms. In this study, genomic libraries were constructed from microbial ...

Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ...

The aerial parts of Clibadium pittierii afforded in addition to known melampolides two new ones, one being esterified with a homoditerpenic acid and the homoditerpenic acid itself. The structures were elucidated by high ...