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Development of immediate release Rupatadine fumarate 10 mg tablets: A Quality by Design (QbD) approach
The main objective of this research is to develop an immediate release Rupatadine fumarate 10 mg tablets formulation by direct compression, through a Quality by Design approach in Costa Rica. Methods: According to a ...
Farmacogenética: hacia la individualización de la terapia farmacológica en Costa Rica
Pharmacogenetics: toward the individualization of pharmacologic therapy in Costa Rica
La ‘era posgenómica’ ha impactado las ciencias biológicas y biomédicas desde la identificación de un significativo componente de variabilidad genética interindividual. La Farmacología no escapa a esta realidad, y esta ...
Combined use of DSC, TGA, XDR and NIR in the compatibility study of preformulation mixtures for the development of 10 mg tablets of Rupatadine Fumarate
It is essential to guarantee physico-chemical compatibility between the active pharmaceutical ingredient (API) and the components that are planned to be used in the development of a pharmaceutical formulation. A successful ...
Furosemide Diuretic Activity Evaluation in Female Sprague-Dawley Rats
This research article focuses on the evaluation of the diuretic activity of Furosemide administered to a group of female Sprague Dawley rats, through the use of metabolic boxes. Methods: A hydration volume of 5 mL/100 g ...
Evaluación de niveles plasmáticos de fenitoína en pacientes del Hospital William Allen (HWAT), Caja Costarricense de Seguro Social (CCSS)
Evaluation of phenytoin plasma levels in patients from Hospital William Allen (HWAT), Social Security Fund (CCSS)
La monitorización terapéutica de fármacos (MTF) es una herramienta válida para optimizar la farmacoterapia ,permitiendo el ajuste en la dosificación de medicamentos,tomando en cuenta las características individuales de ...
Rubus adenotrichus fruit extracts phytochemical characterization and antioxidant power evaluation for dermocosmetic formulations
There are more than 700 species of the genus Rubus, popularly known as Mora (tropical highland blackberry). In Costa Rica, the species Rubus adenotrichus has been characterized by its high content of antioxidant substances, ...
Evaluation of the critical points in the validation of 500 mg levofloxacin tablets for dissolution profile
The method was validated by ultraviolet spectrophotometry for the determination of levofloxacin 500 mg tablets using dissolution profiles to establish therapeutic equivalence. The parameters were satisfactory according ...
Determination of the Impact Caused by Direct Compression on the Crystalline State of Rupatadine Fumarate 10 mg Tablets
The aim of this study is to determine the impact caused by direct compression on the crystalline state of two prototypes of Rupatadine fumarate 10 mg tablets. The tablets were manufactured through direct compression. ...
Physicochemical Characterization of a Liposomal Formulation Based on Glucosamine and Vitamin D, Commercialized as a Nutritional Supplement
In the last years, the transport and release mechanism of bioactive compounds has been studied. The liposomes are multivesicular systems that enhance the absorption, stability, and transport of these compounds. The ...
Quality control performed on liposomal formulations based on guarana extract, vitamins a, c, e, b1, b2, b5, b6, b12, biotin and folic acid, used as nutritional products
The study of has increased in the last decades. One of the mechanisms that has acquired great relevance is to formulate using liposomal vesicles. Liposomes are structures that enh and transport of active compounds, which ...