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Development of immediate release Rupatadine fumarate 10 mg tablets: A Quality by Design (QbD) approach
(2019)
The main objective of this research is to develop an immediate release Rupatadine fumarate 10
mg tablets formulation by direct compression, through a Quality by Design approach in Costa
Rica.
Methods: According to a ...
Farmacogenética: hacia la individualización de la terapia farmacológica en Costa Rica
Pharmacogenetics: toward the individualization of pharmacologic therapy in Costa Rica
(2012-08)
La ‘era posgenómica’ ha impactado las ciencias biológicas y biomédicas desde la identificación de un
significativo componente de variabilidad genética interindividual. La Farmacología no escapa a esta
realidad, y esta ...
Combined use of DSC, TGA, XDR and NIR in the compatibility study of preformulation mixtures for the development of 10 mg tablets of Rupatadine Fumarate
(2018)
It is essential to guarantee physico-chemical compatibility between the active pharmaceutical ingredient (API) and the components that are planned to be used in the development of a pharmaceutical formulation. A successful ...
Furosemide Diuretic Activity Evaluation in Female Sprague-Dawley Rats
(2019)
This research article focuses on the evaluation of the diuretic activity of Furosemide administered to a group of female Sprague Dawley rats, through the use of metabolic boxes.
Methods: A hydration volume of 5 mL/100 g ...
Evaluación de niveles plasmáticos de fenitoína en pacientes del Hospital William Allen (HWAT), Caja Costarricense de Seguro Social (CCSS)
Evaluation of phenytoin plasma levels in patients from Hospital William Allen (HWAT), Social Security Fund (CCSS)
(2012)
La monitorización terapéutica de fármacos (MTF) es una herramienta válida para optimizar la farmacoterapia ,permitiendo el ajuste en la dosificación de medicamentos,tomando en cuenta las características individuales de ...
Rubus adenotrichus fruit extracts phytochemical characterization and antioxidant power evaluation for dermocosmetic formulations
(2017)
There are more than 700 species of the genus Rubus, popularly known as Mora (tropical
highland blackberry). In Costa Rica, the species Rubus adenotrichus has been characterized
by its high content of antioxidant substances, ...
Evaluation of the critical points in the validation of 500 mg levofloxacin tablets for dissolution profile
(2016)
The method was validated by ultraviolet spectrophotometry for the
determination of levofloxacin 500 mg tablets using dissolution profiles
to establish therapeutic equivalence. The parameters were satisfactory
according ...
Determination of the Impact Caused by Direct Compression on the Crystalline State of Rupatadine Fumarate 10 mg Tablets
(2019-11-08)
The aim of this study is to determine the impact caused by direct compression on the crystalline state of two
prototypes of Rupatadine fumarate 10 mg tablets. The tablets were manufactured through direct compression. ...
Physicochemical Characterization of a Liposomal Formulation Based on Glucosamine and Vitamin D, Commercialized as a Nutritional Supplement
(2018)
In the last years, the transport and release mechanism of bioactive compounds has been studied.
The liposomes are multivesicular systems that enhance the absorption, stability, and transport of
these compounds. The ...
Quality control performed on liposomal formulations based on guarana extract, vitamins a, c, e, b1, b2, b5, b6, b12, biotin and folic acid, used as nutritional products
(2017)
The study of has increased in the last decades. One of the mechanisms that has acquired great relevance is to formulate using liposomal vesicles. Liposomes are structures that enh and transport of active compounds, which ...