The main objective of this research is to develop an immediate release Rupatadine fumarate 10 mg tablets formulation by direct compression, through a Quality by Design approach in Costa Rica. Methods: According to a ...

It is essential to guarantee physico-chemical compatibility between the active pharmaceutical ingredient (API) and the components that are planned to be used in the development of a pharmaceutical formulation. A successful ...

La monitorización terapéutica de fármacos (MTF) es una herramienta válida para optimizar la farmacoterapia ,permitiendo el ajuste en la dosificación de medicamentos,tomando en cuenta las características individuales de ...

There are more than 700 species of the genus Rubus, popularly known as Mora (tropical highland blackberry). In Costa Rica, the species Rubus adenotrichus has been characterized by its high content of antioxidant substances, ...

The method was validated by ultraviolet spectrophotometry for the determination of levofloxacin 500 mg tablets using dissolution profiles to establish therapeutic equivalence. The parameters were satisfactory according ...

The aim of this study is to determine the impact caused by direct compression on the crystalline state of two prototypes of Rupatadine fumarate 10 mg tablets. The tablets were manufactured through direct compression. ...

Polymorphism analysis of pharmaceutical raw materials is considered one of the most relevant evaluations that should be done. As we know, different crystal forms from the same molecule have differences in terms of their ...

Introduction: Since 2009 the University of Costa Rica, through the Faculty of Pharmacy, is dedicated to promote a model of development in cosmetics in small and medium industries in rural or poorest areas of Costa Rica, ...

Costa Rica is a volcanic country, containing a variety of peloids with different physicochemical properties; also its main source of income is the tourism. Most of their abundant natural resources have not been characterized ...

Design of Experiments (DoE) is a statistical model that aims to determine if the factors under study affect the response, and if so, it determines the conditions under which this variable of interest can be optimized. In ...