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Clinical and Genetic Analysis of Costa Rican Patients With Parkinson's Disease
(2021-08-04)
La mayor parte de la investigación en genómica de la enfermedad de Parkinson (EP) se ha realizado en sujetos de ascendencia europea, lo que genera un sesgo de muestreo y deja a las poblaciones latinoamericanas subrepresentadas. ...
Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens
(Behavioural Brain Research, Vol. 252. pp. 77-87, 2013)
The study of individual differences provides an important methodological approach to analyze the
neurobehavioral spectrum of a given cohort in order to understand brain function and disease. Based
on immobility time in ...
A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries
(1993)
A video image analyzing system is presented which measures turning behavior, thigmotactic scanning and locomotion in rats. The system works by analyzing digitized video images obtained by a black/white video camera. Turning ...
Time course of deficits in open field behavior after unilateral neostriatal 6-hydroxydopamine lesions
(2002)
In this study, the degree and time course of deficits in open field behavior was analyzed in male Wistar rats (aged 1 year) which had received unilateral neostriatal lesions with 6-OHDA. The post-mortem neurochemical ...
Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats
(2018-03-13)
In laboratory rats, one of the most used paradigms to assess habituation to novelty is the open-field test.
Environmental enrichment has proved to be a reliable way to enhance open-field test habituation.
Experiment 1, ...
Individual differences in the forced swimming test and neurochemical kinetics in the rat brain
(Physiology & Behavior 126(1):60-69, 2014-02-08)
Individual differences in the forced swimming test (FST) could be associatedwith differential temporal dynamics
of gene expression and neurotransmitter activity. We tested juvenile male rats in the FST and classified ...
Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion
(1999)
1. Rats which had received a unilateral injection of 6-OHDA into the substantia nigra were assigned to four lesion groups according to the degree of DA depletion in the neostriatum. In these animals, behavioral changes in ...
A Protocol to Perform Systemic Lipopolysacharide (LPS) Challenge in Rats
Protocolo para realizar reto sistémico con lipopolisacárido (LPS) en ratas
(2019-01-01)
Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. In animals, intraperitoneal administration of LPS, stimulates innate immunity and the production of ...
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
(2019-11)
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However,
CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents,
despite the evidence ...
Enfermedad de Alzheimer en Costa Rica. Una realidad poco investigada
(2018)
El incremento de la población adulta mayor en nuestro país ha generado una mayor
prevalencia de varias enfermedades, entre ellas las de tipo cognitivo como lo es la
Enfermedad de Alzheimer (EA). El propósito de este ...