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Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens
(Behavioural Brain Research, Vol. 252. pp. 77-87, 2013)
The study of individual differences provides an important methodological approach to analyze the
neurobehavioral spectrum of a given cohort in order to understand brain function and disease. Based
on immobility time in ...
A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries
(1993)
A video image analyzing system is presented which measures turning behavior, thigmotactic scanning and locomotion in rats. The system works by analyzing digitized video images obtained by a black/white video camera. Turning ...
Time course of deficits in open field behavior after unilateral neostriatal 6-hydroxydopamine lesions
(2002)
In this study, the degree and time course of deficits in open field behavior was analyzed in male Wistar rats (aged 1 year) which had received unilateral neostriatal lesions with 6-OHDA. The post-mortem neurochemical ...
Early behavioral changes after nigro-striatal system damage can serve as predictors of striatal dopamine depletion
(1999)
1. Rats which had received a unilateral injection of 6-OHDA into the substantia nigra were assigned to four lesion groups according to the degree of DA depletion in the neostriatum. In these animals, behavioral changes in ...
A Protocol to Perform Systemic Lipopolysacharide (LPS) Challenge in Rats
Protocolo para realizar reto sistémico con lipopolisacárido (LPS) en ratas
(2019-01-01)
Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. In animals, intraperitoneal administration of LPS, stimulates innate immunity and the production of ...
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
(2019-11)
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However,
CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents,
despite the evidence ...
Enfermedad de Alzheimer en Costa Rica. Una realidad poco investigada
(2018)
El incremento de la población adulta mayor en nuestro país ha generado una mayor
prevalencia de varias enfermedades, entre ellas las de tipo cognitivo como lo es la
Enfermedad de Alzheimer (EA). El propósito de este ...
Stress-Induced Microglia Activationand Monocyte Trafficking to the BrainUnderlie the Development of Anxietyand Depression
(2016)
Psychosocial stress is capable of causing immune dysregulation and increased neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic systems that may contribute to the development of anxiety ...
Analogía computacional del cerebro y la mente
(1998)
En los últimos dos siglos se ha dado un especial interés por desentrañar los misterios que
rodean a la mente y al cerebro. Es más, esta separación ha hecho suponer que la mente es
una cuestión de orden espiritual y que ...
Efecto de los analgésicos dipirona, tramadol y meloxicam en el comportamiento de ratas de laboratorio
Effect of the analgesics dipyrone, tramadol, and meloxicam on the behavior of laboratory rats
(2022-11)
Awareness about the ethical use of laboratory animals has increased over recent decades alongside the development of strict guidelines and legislation concerning the welfare of animals in scientific research. Although ...