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El papel de la microglía en la señalización neuroinflamatoria y la respuesta neuroinmune
(2016)
La neuroinflamación consiste en un estado reactivo del componente inmune en el sistema nervioso, y se encuentra mediada por efectores celulares, como la microglía y los astrocitos, y efectores moleculares solubles como ...
A high performance liquid chromatography method with electrochemical detection of gamma-aminobutyric acid, glutamate and glutamine in rat brain homogenates
(2009)
Determination of γ-aminobutyric acid (GABA), glutamate (Glu) and glutamine (Gln) in animal models has been important to understand the normal function and clinical aspects of some neurological diseases. Quantification of ...
Aportes de la Neurociencia al entendimiento del desarrollo en los primeros años de vida
(2011)
En su informe parcial de labores, de media-dos del 2010, el Programa de Investigación en Neurociencias de la UCR y el Departamento de Educación Preescolar del MEP señalaron algunos retos puntuales para el mejoramiento del ...
A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats
(2009-01-30)
Our previous work has shown that male Sprague–Dawley rats reared in social isolation, standard housing and environmental enrichment differ in their spontaneous open-field activity and in some neurobehavioral depressive-like ...
En busca de un modelo preclínico de la enfermedad de Parkinson. Segunda parte
(1998)
En la Primera parte de este artículo, expuse muy brevemente, algunas de las características de la enfermedad del Parkinson y sobre todo lo difícil que ha sido a lo largo de la historia encontrar una terapéutica realmente ...
Fat Intake and obesity-related parameters predict striatal BDNF gene expression and dopamine metabolite levels in cafeteria diet-fed rats
(2022-04)
Modern westernized diet is a major risk factor associated with the current obesity epidemic. To study the effects of dietary choices of Western societies, the cafeteria diet has been validated as a preclinical model of ...
Association of Apolipoprotein E-e4 and Dementia Declines with Age
(2014-10)
To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).
In both case-control ...
Methylmercury increases S100B content in rat cerebrospinal fluid
(2005-02)
S100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury ...
Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
(1993-02)
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
Clinical and Genetic Analysis of Costa Rican Patients With Parkinson's Disease
(2021-08-04)
La mayor parte de la investigación en genómica de la enfermedad de Parkinson (EP) se ha realizado en sujetos de ascendencia europea, lo que genera un sesgo de muestreo y deja a las poblaciones latinoamericanas subrepresentadas. ...