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Adjudicating Neurocognitive Endophenotypes for Schizophrenia
(American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 144B:242–249 (2007), 2007-03-05)
Although genetic influences on schizophrenia
are well established, localization of the genes
responsible for this illness has proven extremely
difficult. Given evidence that genes predisposing
to schizophrenia may be ...
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families
(Arch Gen Psychiatry. 2010;67(2):168-177, 2010-02-01)
Context: Although genetic influences on bipolar disorder
are well established, localization of genes that predispose
to the illness has proven difficult. Given that genes
predisposing to bipolar disorder may be transmitted ...
Shared Genetic Factors Influence Risk for Bipolar Disorder and Alcoholism
(2014-06)
Bipolar disorder and alcoholism have high rate comorbidity, with more than 50% of alcoholism
occurrence in bipolar disorder. While there is evidence that both disorders are heritable, it is unclear
if the same genetic ...
Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
(Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
Bipolar disorder (BPD) has been associated with variations in personality dimensions,
but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig
Five personality factors and the ...
Heritability of Age of Onset of Psychosis in Schizophrenia
(AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...
A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study
(Am J Psychiatry 2009;166:442-449, 2009-02-02)
The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica
(J Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782., 2011)
We sought to identify cognitive phenotypes for family/genetic studies of successful cognitive
aging (SCA; maintaining intact cognitive functioning while living to late old age).We
administered a battery of neuropsychological ...