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Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
(2008)
Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity
was assessed at postnatal days 37, 65, 93 and 107 and 1 h before the last ...
Physiological wear-and-tear and later subjective health in mid-life: Findings from the 1958 British birth cohort
(2016)
Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated ...
Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats
(2013)
Maternal care plays an important role as an early modeler of neurodevelopment and brain function,
and its effects remain until adulthood. Such modeling or programming has shown to influence the
stress response and ...
Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells
(2019)
Gastric carcinomas (GC) are heterogeneous tumors, composed of a subpopulation of cluster of differentiation-44 (CD44)+ tumorigenic and chemoresistant cancer stem cells (CSC). YAP1 and TAZ oncoproteins (Y/T) interact with ...
The effect of chronic fluoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum
(2009-03-02)
This study examined the effect of fluoxetine, a selective serotonin (5-HT) reuptake inhibitor, on isolation-induced changes on sucrose consumption and preference, spontaneous open-field activity, forced swimming behavior, ...
Amerindian ancestry and extended longevity in Nicoya, Costa Rica
(2018-01)
Objectives: The aim of this study was to address the hypothesis that Amerindian
ancestry is associated with extended longevity in the admixed population of Nicoya,
Costa Rica. The Nicoya Peninsula of Costa Rica has been ...
Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats
(2013)
Maternal care represents a major constituent of early life environment and has the potential to modulate critical
neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally ...
DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria
(2019)
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved ...
Contaminación del agua del río Durazno, Costa Rica: más allá del índice holandés de calidad del agua
Pollution of the Durazno River water, Costa Rica: beyond the Dutch water quality index
(2023-06-01)
Introduction: The micro-basin of the Durazno River in Costa Rica is a source of water for human consumption, but is suspected of microbiological pollution from several land uses. Objective: To assess the water quality of ...
Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents
(2019-01)
Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized
and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds
were also evaluated. The ...