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Association of Apolipoprotein E-e4 and Dementia Declines with Age
(2014-10)
To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).
In both case-control ...
En busca de un modelo preclínico de la enfermedad de Parkinson. Segunda parte
(1998)
En la Primera parte de este artículo, expuse muy brevemente, algunas de las características de la enfermedad del Parkinson y sobre todo lo difícil que ha sido a lo largo de la historia encontrar una terapéutica realmente ...
Enfermedad de Alzheimer en Costa Rica. Una realidad poco investigada
(2018)
El incremento de la población adulta mayor en nuestro país ha generado una mayor
prevalencia de varias enfermedades, entre ellas las de tipo cognitivo como lo es la
Enfermedad de Alzheimer (EA). El propósito de este ...
Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats
(2018-03-13)
In laboratory rats, one of the most used paradigms to assess habituation to novelty is the open-field test.
Environmental enrichment has proved to be a reliable way to enhance open-field test habituation.
Experiment 1, ...
Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens
(Behavioural Brain Research, Vol. 252. pp. 77-87, 2013)
The study of individual differences provides an important methodological approach to analyze the
neurobehavioral spectrum of a given cohort in order to understand brain function and disease. Based
on immobility time in ...
Individual differences in the forced swimming test and neurochemical kinetics in the rat brain
(Physiology & Behavior 126(1):60-69, 2014-02-08)
Individual differences in the forced swimming test (FST) could be associatedwith differential temporal dynamics
of gene expression and neurotransmitter activity. We tested juvenile male rats in the FST and classified ...
El papel de la microglía en la señalización neuroinflamatoria y la respuesta neuroinmune
(2016)
La neuroinflamación consiste en un estado reactivo del componente inmune en el sistema nervioso, y se encuentra mediada por efectores celulares, como la microglía y los astrocitos, y efectores moleculares solubles como ...
A Protocol to Perform Systemic Lipopolysacharide (LPS) Challenge in Rats
Protocolo para realizar reto sistémico con lipopolisacárido (LPS) en ratas
(2019-01-01)
Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. In animals, intraperitoneal administration of LPS, stimulates innate immunity and the production of ...
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
(2019-11)
The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However,
CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents,
despite the evidence ...
Fat Intake and obesity-related parameters predict striatal BDNF gene expression and dopamine metabolite levels in cafeteria diet-fed rats
(2022-04)
Modern westernized diet is a major risk factor associated with the current obesity epidemic. To study the effects of dietary choices of Western societies, the cafeteria diet has been validated as a preclinical model of ...