Now showing items 1-2 of 2

    • High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees 

      Castri, Loredana; Barrantes Mesén, Ramiro; Pereira Reyes, Reinaldo; Luiselli, Donata; Pettener, Davide; Barbujani, Guido; Madrigal, Lorena; Meléndez Obando, Mauricio O.; Villegas Palma, Ramón; Raventós Vorst, Henriette (American Journal of Physical Anthropology 2012 July ; 148(3): 327–333., 2012-07)
      Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA (mtDNA) vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) ...
    • Mitochondrial polymorphisms are associated both with increased and decreased longevity 

      Castri, Loredana; Meléndez Obando, Mauricio O.; Villegas Palma, Ramón; Barrantes Mesén, Ramiro; Raventós Vorst, Henriette; Pereira Reyes, Reinaldo; Luiselli, Donata; Pettener, Davide; Madrigal, Lorena (Hum Hered 2009;67:147–153, 2008-12-15)
      Previous work compared frequency of longevity-associated polymorphisms (LAPS) in long-lived individuals and in controls from the general population (primarily in Europe and Japan), suggesting the polymorphisms are responsible ...