Microbiología
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What lies behind the curtain: Cryptic diversity in helminth parasites of human and veterinary importance
(2022)Parasite cryptic species are morphologically indistinguishable but genetically distinct organisms, leading to taxa with unclear species boundaries. Speciation mechanisms such as cospeciation, host colonization, taxon ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
(2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells
(2021-09-18)In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an ... -
Fluorescence Imaging Approaches in Flavivirus Research
(2021-10-01)The genus Flavivirus within the family Flaviviridae contains many arthropod-borne infectious agents of medical relevance like dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV), among others, that cause ... -
Generation and implementation of reporter BHK-21 cells for live imaging of flavivirus infection
(2021-03-05)The genus Flavivirus within the family Flaviviridae includes many viral species of medical importance, such as yellow fever virus (YFV), Zika virus (ZIKV), and dengue virus (DENV), among others. Presently, the identification ... -
In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides
(2021-09-15)Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant during recent outbreaks in Latin America due to its unrecognized association with fetal neurological disorders. Currently, there ... -
A fluorescence-activatable reporter of flavivirus NS2B–NS3 protease activity enables live imaging of infection in single cells and viral plaques
(2020-01-09)The genus Flavivirus in the family Flaviviridae comprises many medically important viruses, such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus. The quest for thera- peutic targets to combat flavivirus ... -
A Fluorescent Real-Time Plaque Assay Enables Single-Cell Analysis of Virus-Induced Cytopathic Effect by Live-Cell Imaging
(2021-06-22)Conventional plaque assays rely on the use of overlays to restrict viral infection allowing the formation of distinct foci that grow in time as the replication cycle continues leading to countable plaques that are ... -
Promoting co-existence between humans and venomous snakes through increasing the herpetological knowledge base
(2021)Snakebite incidence at least partly depends on the biology of the snakes involved. However, studies of snake biology have been largely neglected in favour of anthropic factors, with the exception of taxonomy, which has been ... -
Characterization of Extracellular Vesicles Secreted by a Clinical Isolate of Naegleria fowleri and Identification of Immunogenic Components within Their Protein Cargo
(2022-06)Abstract: Extracellular vesicles (EVs) are small lipid vesicles released by both prokaryotic and eu-karyotic cells, involved in intercellular communication, immunomodulation and pathogenesis. In this study, we performed a ... -
Highlights in Suicidal Ideation and Non-suicidal self-injury in Costa Rica children and Adolescents
(2022)Suicidal ideation and deliberate self-harm prevalence has markedly increased among youngsters over the past two decades. The objective of the work was to determine the prevalence and factors associated with deliberate ... -
Prevalencia de riesgo cardiometabólico en una muestra nacional de jóvenes costarricenses utilizando el indicador antropométrico cintura-estatura
(2022)La obesidad central es un indicador de riesgo cardiometabólico, pero se necesitan mejores medidas antropométricas que el Índice de Masa Corporal (IMC) para detectarlo. La relación cintura-estatura (WHtR) es un indicador ... -
Duración de la lactancia materna, alimentación combinada y riesgo para la salud en jóvenes costarricenses
(2022)Objetivo: examinar la asociación entre la duración de la lactancia materna y la alimentación mixta con la obesidad, riesgo cardiometabólico, grasa corporal, conductas de riesgo dietéticas y de actividad física en niños ... -
In vitro Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors
(2022)Despite vaccines are the main strategy to control the ongoing global COVID-19 pandemic, their effectiveness could not be enough for individuals with immunosuppression. In these cases, as well as in patients with ... -
Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer
(2020-10)Gastric mucosa tumors may present as two distinct major entities: Diffuse and intestinal subtypes. There is no standard treatment for advanced or metastatic gastric cancer. The mevalonate pathway and cholesterol homeostasis ... -
Importance of mevalonate pathway lipids on the growth and survival of primary and metastatic gastric carcinoma cells
(2021)Purpose: This preclinical study aims to determine the effect of drugs that alter isoprenoids and cholesterol metabolism in the homeostasis of gastric carcinoma cell lines in the search for new therapeutic targets for stomach ... -
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis. Although several SARS-CoV-2 vaccines have ... -
Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms
(2021-11)The lethality neutralization assay in mice is the gold standard for the evaluation of the preclinical efficacy and specification fulfillment of snake antivenoms. However, owing to the animal suffering involved, this assay ... -
Modelo de lógica difusa como alternativa para la evaluación de la satisfacción de usuarios del laboratorio clínico
(2014)La calidad consiste en un conjunto de características propias de un producto a nivel de variabilidad y cumplimiento de los requerimiento del cliente, el cual también incluye el cómo se brinda el servicio a éste. Una de ... -
Alterations in common marmoset gut microbiome associated with duodenal strictures
(2022-03-28)Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets (Callithrix jacchus). Despite standardized housing, diet and husbandry, a recently described gastrointestinal syndrome ...
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