Microbiología
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Patient Safety Indicators in Clinical Laboratories: An Exploratory Survey among Costa Rican Laboratory Professionals
(2021-02-13)Introduction: Patient safety indicators (PSIs) focus on the prevention of complications and minimization of unnecessary patient risk. Using the methodology known as SMART, the most suitable indicators may be selected by ... -
Gene expression analyses of gingival tissue of patients with periodontitis using public transcriptomic data
(2022-11)Abstract—Periodontal disease (PD) is a multifactorial and chronic condition of infection and inflammation of the gingival tissue. However, many of the biological and molecular mechanisms regarding the development of this ... -
Stable production of recombinant SARS-CoV-2 receptor-binding domain in mammalian cells with co-expression of a fluorescent reporter and its validation as antigenic target for COVID-19 serology testing
(2023-01)SARS-CoV-2 receptor binding domain (RBD) recognizes the angiotensin converting enzyme 2 (ACE2) receptor in host cells that enables infection. Due to its antigenic specificity, RBD production is important for development ... -
Quantification of snake venom proteomes by mass spectrometry-considerations and perspectives.
(2023-05-08)The advent of soft ionization mass spectrometry-based proteomics in the 1990s led to the development of a new dimension in biology that conceptually allows for the integral analysis of whole proteomes. This transition from ... -
Antibodies against a single fraction of Micrurus dumerilii venom neutralize the lethal effect of whole venom
(2023-02-01)The coralsnake Micrurus dumerilii (Elapidae) is reported to cause envenomings of medical importance. Previous studies characterized the protein composition of its venom, with phospholipase A2 (PLA2) proteins the most ... -
Discovery and optimization of a broadly-neutralizing human antibody against long-chain α-neurotoxins from snakes
(2023-02-08)Snakebite envenoming continues to claim many lives across the globe, necessitating the development of improved therapies. To this end, broadly-neutralizing human monoclonal antibodies may possess advantages over current ... -
Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?
(2023)Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned ... -
Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: a comprehensive review
(2023)Muscle necrosis is a potential clinical complication of snakebite envenomings, which in severe cases can lead to functional or physical sequelae such as disability or amputation. Snake venom proteins with the ability to ... -
Evaluación de la utilidad como biomarcador del ADN circulante tumoral para el monitoreo de los estadios clínicos y funcionales en pacientes con cáncer de mama
(2023-04)El cáncer comprende un conjunto de enfermedades con alta incidencia y mortalidad. En Costa Rica, el cáncer de mama es el más frecuente en las mujeres y el primer lugar en mortalidad. Sin embargo, las estrategias de tamizaje ... -
Half a century of research on Bothrops asper venom variation: biological and biomedical implications
(2022)Snake venoms are a complex biological mixture of proteins with or without enzymatic activity, peptides, and nucleotides, among other components. It is produced in specialized secretory glands located in the maxillary region, ... -
Focal Philophthalmus gralli infection possibly persists in Melanoides tuberculata over two years following the definitive hosts' removal
(2014)Philophthalmosis is a zoonotic disease associated largely with the spread of the invasive freshwater snail Melanoides tuberculata, serving as an intermediate host. Here we examined Philophthalmus gralli focal fenced infection ... -
Pathology and first report of natural eye infection with the trematode Philophthalmus gralli (Digenea, Philophthalmidae) in Tinamus major (Tinamiformes, Tinamidae), Costa Rica
(2013)The eye-fluke Philophthalmus gralli (Philophthalmidae Looss, 1899) was found in six birds known as great tinamous (Tinamusmajor) reared in awild animal shelter located in Alajuela, Costa Rica. The birds presented conjunctival ... -
Detection of Dirofilaria immitis and other arthropod-borne filarioids by an HRM real-time qPCR, blood-concentrating techniques and a serological assay in dogs from Costa Rica
(2015)Background: Canine filarioids are important nematodes transmitted to dogs by arthropods. Diagnosis of canine filariosis is accomplished by the microscopic identification of microfilariae, serology or PCR for filarial-DNA. ... -
Venomics of the scorpion Tityus ocelote (Scorpiones, Buthidae): Understanding venom evolution in the subgenus Archaeotityus
(2022)The subgenus Tityus (Archaeotityus) includes small variegated species considered until recently, a basal group within Tityus, one of the most diverse and medically relevant genera of scorpions in the New World. Archaeotityus ... -
Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib
(2023)Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. ... -
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection
(2014)Infection with canine vector-borne pathogens was evaluated in dogs from four different regions of Costa Rica by PCR. Demographic data, clinical signs, packed cell volume values, and the presence of tick infestation were ... -
Acanthamoeba genotype T4 keratitis in a patient with Thygeson’s superficial punctate keratitis
(2017-01)A case of amoebic keratitis due to Acanthamoeba genotype T4 is reported. The patient is a 74-year old woman with Thygeson’s superficial punctate keratitis. Corneal scrapings were employed for the diagnosis, which included ... -
Isolation and molecular characterization of Acanthamoeba and Balamuthia mandrillaris from combination shower units in Costa Rica
(2014-08-19)Free living amoebae (FLA) are ubiquitous protozoa, which may behave as parasites under certain conditions. Four genera are recognized as causal agents of infections in humans and animals: Naegleria, Sappinia, Acanthamoeba ... -
Amebas de vida libre como agentes de encefalitis en el ser humano
(2014-07)Este artículo de revisión se enfoca en las amebas de vida libre, un tipo de protozoarios que habitan diferentes tipos de suelo y fuentes de agua. Estos organismos tienen dos estadios evolutivos: trofozoíto y quiste, siendo ...
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