Microbiología
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Análisis de la concordancia entre los resultados del panel molecular de neumonía BIOFIRE® FILMARRAY® y el cultivo bacteriano de muestras respiratorias procesadas en el laboratorio clínico del Hospital Dr. R. A. Calderón Guardia durante el periodo julio 2020 – julio 2021
(2023)La neumonía es un cuadro clínico que ocurre con la invasión del tracto respiratorio inferior por uno o varios microorganismos, bacterianos o virales. Es una causa importante de mortalidad y morbilidad a nivel mundial, y ... -
Infecciones virales en el sistema nervioso central: actualización en la inmunología anti-viral en el sistema nervioso central y evasión inmune viral
(2022)Las infecciones en el SNC tienen una gran importancia porque generan una alta mortalidad, además de provocar secuelas importantes en la personas que sobreviven. Muchos agentes virales pueden provocar patologías en el SNC, ... -
The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor
(2022)Snake envenoming is a major but neglected human disease in tropical and subtropical regions. Among venomous snakes in the Americas, coral snakes of the genus Micrurus are particularly dangerous because they cause a peripheral ... -
Characterization of Extracellular Vesicles Secreted by a Clinical Isolate of Naegleria fowleri and Identification of Immunogenic Components within Their Protein Cargo
(2022-06)Abstract: Extracellular vesicles (EVs) are small lipid vesicles released by both prokaryotic and eu-karyotic cells, involved in intercellular communication, immunomodulation and pathogenesis. In this study, we performed a ... -
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom.
(2022)The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming ... -
In vivo neutralization of Myotoxin II, a phospholipase A2 homolog from Bothrops asper venom, using peptides discovered via phage display technology
(2022)Many snake venom toxins cause local tissue damage in prey and victims, which constitutes an important pathology that is challenging to treat with existing antivenoms. One of the notorious toxins that causes such effects ... -
Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats
(2022)In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus ... -
Solving the microheterogeneity of Bothrops asper myotoxin-II by high-resolution mass spectrometry: insights into C-terminal region variability in Lys49-phospholipase A2 homologs
(2022)Myotoxin-II, a phospholipase A2 (PLA2)-like protein found in Bothrops asper venom, causes rapid necrosis of muscle fibers in spite of lacking enzymatic activity. This toxic action maps to its C-terminal region, within a ... -
First insights into the venom composition of two Ecuadorian coral snakes
(2022)Micrurus is a medically relevant genus of venomous snakes composed of 85 species. Bites caused by coral snakes are rare, but they are usually associated with very severe and life-threatening clinical manifestations. Ecuador ... -
Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: The long-tailed rattlesnakes
(2022)The most enigmatic group of rattlesnakes is the long-tailed rattlesnake group, consisting of three species: Crotalus ericsmithi, Crotalus lannomi and Crotalus stejnegeri. These species have been the least studied rattlesnakes ... -
Optimización de la fermentación de Trichoderma Asperellum para la producción y caracterización de peptaiboles con potencial efecto antimicrobiano contra patógenos alimentarios
(2022)Las Enfermedades Transmitidas por Alimentos (ETA) son causadas por microorganismos y sustancias químicas en diversas matrices alimenticias. Estas enfermedades son una problemática a nivel mundial, ya que afectan la salud ... -
Sphingolipid pathway as a biosensor of cancer chemosensitivity: a proof of principle
(2022-12)Cancer is a complex genetic disease with reduced treatment alternatives due to tumor heterogeneity and drug multiresistance emergence. The sphingolipid (SL) metabolic pathway integrates different responses of cellular ... -
Two-dimensional gel electrophoresis image analysis of two Pseudomonas aeruginosa clones
(2022-11-17)A classical strategy to analyse the protein content of a biological sample is the two-dimensional gel electrophoresis (2D-GE). This technique separates proteins by both isoelectric point and molecular weight, and images ... -
Dermatofitos: una revisión en la literatura desde la perspectiva del laboratorio clínico
(2022)Los dermatofitos son un grupo de hongos de importancia médica que causan micosis superficiales, sus agentes etiológicos están relacionados entre sí por compartir ciertas características y colonizar la epidermis en su ... -
Caracterización bioquímica y biológica de inhibidores endógenos de veneno presentes en el plasma de la serpiente Crotalus simus (Serpentes: Viperidae)
(2022)Las serpientes venenosas presentan una mezcla compleja de toxinas de origen proteico con diferentes actividades farmacológicas. Un mecanismo de resistencia que las serpientes y otros organismos presentan contra estas toxinas ... -
Consecuencias biológicas de las variaciones en los dominios de unión a receptor de toxina B de cepas clásicas e hipervirulentas de Clostridioides difficile
(2022)Clostridioides difficile es un bacilo anaerobio estricto, Gram positivo y formador de esporas. Es un patógeno oportunista que coloniza el colon del hospedero cuando se altera la microbiota intestinal favoreciendo la ... -
What lies behind the curtain: Cryptic diversity in helminth parasites of human and veterinary importance
(2022)Parasite cryptic species are morphologically indistinguishable but genetically distinct organisms, leading to taxa with unclear species boundaries. Speciation mechanisms such as cospeciation, host colonization, taxon ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
(2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ... -
Perturbation-Based Modeling Unveils the Autophagic Modulation of Chemosensitivity and Immunogenicity in Breast Cancer Cells
(2021-09-18)In the absence of new therapeutic strategies, chemotherapeutic drugs are the most widely used strategy against metastatic breast cancer, in spite of eliciting multiple adverse effects and having low responses with an ... -
Fluorescence Imaging Approaches in Flavivirus Research
(2021-10-01)The genus Flavivirus within the family Flaviviridae contains many arthropod-borne infectious agents of medical relevance like dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV), among others, that cause ...
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