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Pros and cons of different therapeutic antibody formats for recombinant antivenom development
(2018-05)
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many
advances in immunology, synthetic biology, and antibody research, different approaches and antibody
formats are being ...
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern
(2021)
SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and
therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We
tested therapeutic equine polyclonal antibodies (pAbs) ...
Characterization of Extracellular Vesicles Secreted by a Clinical Isolate of Naegleria fowleri and Identification of Immunogenic Components within Their Protein Cargo
(2022-06)
Abstract: Extracellular vesicles (EVs) are small lipid vesicles released by both prokaryotic and eu-karyotic cells, involved in intercellular communication, immunomodulation and pathogenesis. In this study, we performed a ...
Extracellular vesicles of Trypanosoma cruzi and immune complexes they form with sialylated and non-sialylated IgGs increase small peritoneal macrophage subpopulation and elicit different cytokines profiles
(2023)
American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite Trypanosoma cruzi and is characterized by the presence of cardiac or gastrointestinal symptoms in a large number of patients during the chronic ...
Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo)
(1992-10)
Histological and ultrastructural alterations in capillary blood vessels were studied at various time intervals after im injection of 50 micrograms of Bothrops asper snake venom in mouse gastrocnemius muscle. Hemorrhage was ...
Primer aislamiento de Balamuthia mandrillaris en Costa Rica
(2014-07)
En este estudio se determinó la presencia de Balamuthia mandrillaris en una muestra de polvo procedente de una unidad combinada de emergencia en Costa Rica. Se realizó un muestreo de polvo y agua en 12 unidades combinadas ...
Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms
(2003)
Lys49 phospholipase A2 homologues constitute a group of catalytically-inactive proteins, present in the venoms of many
crotalid snakes, which induce myonecrosis. Current evidence supports the mapping of their toxic site ...