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Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
(2018-08)
Background: the epidemiology of Clostridium difficile infections (CDI) is changing rapidly worldwide; knowledge on the genotypes of C. difficile circulating in specialized geriatric hospitals and their resistance to ...
Bioavailability of in-feed tetracyclines is influenced to a greater extent by crude protein rather than calcium
(2014-12)
Feed is a common vehicle for tetracycline administration in animal farming. However, veterinarians and farmers often overlook that common feed components, such as proteins and calcium, may interact with these drugs and ...
Zoonotic Agents in Feral Pigeons (Columba livia) from Costa Rica: Possible Improvements to Diminish Contagion Risks
(2018-01)
Most studies on zoonotic agents in pigeons have been conducted in the Palearctic region, but the scarcity of data is notorious in the Neotropical region, where these birds can breed all year around and are in close contact ...
Scarce detection of mobile erm genes associated with tetQ in Bacteroides and Parabacteroides from Costa Rica
(2013-06)
The frequency of finding of clindamycin-resistant anaerobic bacteria in clinical samples has doubled from 2008 to 2010 in Costa Rica. To determine whether this increase is due to dissemination of erm genes aided by tetQ ...
Exposure of a Tropical Soil to mg/kg of Oxytetracycline Elicits Hormetic Responses in the Catabolic Activities of its Microbial Community
(2011-04)
Many farmers in developing countries protect their crops with oxytetracycline and fertilize their farmlands with manure from animals that received this drug as growth promoter. In this study, a tropical soil was exposed ...
A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption
(2016-08)
The epidemiology of Clostridium difficile infections is highly dynamic as new strains continue to emerge worldwide. Here we present a detailed analysis of a new C. difficile strain (ICC-45) recovered from a cancer patient ...
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Bioinformatics advances in Costa Rica: Retrospective view and perspectives
(2021-11-09)
Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
(2016-03)
Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased
pathogenic potential of these strains has been attributed to several factors but is still ...
Predominance and high antibiotic resistance of the emerging Clostridium difficile genotypes NAPCR1 and NAP9 in a Costa Rican hospital over a 2-year period without outbreaks
(2016-05)
Clostridium difficile is the major causative agent of nosocomial antibiotic-associated diarrhea. In a 2009 outbreak of C. difficileassociated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent ...
Spraying of oxytetracycline and gentamicin onto field-grown coriander did not affect the abundance of resistant bacteria, resistance genes, and broad host range plasmids detected in tropical soil bacteria
(2008-03)
Horticultural supplements containing oxytetracycline and gentamicin, two clinically relevant biocides, are widely marketed to prevent or control infections by bacterial phytopathogens. Despite their regular consumption in ...