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Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)
Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2
virus, define a large spectrum of symptoms that are mainly dependent on the human host
conditions. In Costa Rica, almost 319 000 cases ...
Two-dimensional gel electrophoresis image analysis of two Pseudomonas aeruginosa clones
Análisis de imágenes bidimensionales de electroforesis en gel de dos clones de Pseudomonas aeruginosa
(2022-11-17)
A classical strategy to analyse the protein content of a biological sample is the two-dimensional
gel electrophoresis (2D-GE). This technique separates proteins by both isoelectric point and
molecular weight, and images ...
Metagenomic pipeline for identifying co-infections among distinct SARS-CoV-2 variants of concern: Study cases from Alpha to Omicron
(2022)
Concomitant infection or co-infection with distinct SARS-CoV-2 genotypes have been reported as part of
the epidemiological surveillance of the COVID-19 pandemic. In the context of the spread of more
transmissible variants ...
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Bioinformatics advances in Costa Rica: Retrospective view and perspectives
(2021-11-09)
Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)
Cancer is a group of heterogeneous and complex
diseases, with limited therapeutic options due to the recurrent
emergence of drug resistance. Sphingolipids are bioactive
molecules that participate in signaling of cell ...
A hybrid mathematical modeling approach of the metabolic fate of a fluorescent sphingolipid analogue to predict cancer chemosensitivity
(2018-06)
Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate ...
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)
Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ...
High quality 3C de novo assembly and annotation of a multidrug resistant ST-111 Pseudomonas aeruginosa genome: Benchmark of hybrid and non-hybrid assemblers
(2020)
Genotyping methods and genome sequencing are indispensable to reveal genomic structure of bacterial species displaying high level of genome plasticity. However, reconstruction of genome or assembly is not straightforward ...
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern
(2021)
SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and
therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We
tested therapeutic equine polyclonal antibodies (pAbs) ...