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Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins
(2015-06)
The venom proteome of the monocled cobra, Naja kaouthia, from Thailand, was characterized by RPHPLC,
SDS-PAGE, and MALDI-TOF-TOF analyses, yielding 38 different proteins that were either identified
or assigned to families. ...
Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus
(2017)
Snakebite envenomings represent a neglected public health issue in many parts of the
rural tropical world. Animal-derived antivenoms have existed for more than a hundred
years and are effective in neutralizing snake venom ...
From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy
(2016)
The snake is the symbol of medicine due to its association with Asclepius, the
Greek God of medicine, and so with good reasons. More than 725 species of venomous
snakes have toxins specifically evolved to exert potent ...
Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca
(2017-01-06)
A toxicovenomic analysis of the venomof the forest cobra, N. melanoleuca,was performed, revealing the presence
of a total of 52 proteins by proteomics analysis. The most abundant proteins belong to the three-finger ...
Discovery and optimization of a broadly-neutralizing human antibody against long-chain α-neurotoxins from snakes
(2023-02-08)
Snakebite envenoming continues to claim many lives across the globe, necessitating the development of improved therapies. To this end, broadly-neutralizing human monoclonal antibodies may possess advantages over current ...
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
(2020)
In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ...
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score
(2015-09-15)
For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ...
Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping
(2017-07)
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies
purified from the blood of hyper-immunized animals. Knowledge on antibody recognition
sites (epitopes) on snake venom proteins ...
An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity
(2020)
Snakebite envenoming is a major neglected tropical disease that affects millions of people every year. The only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies ...
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom.
(2022)
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming ...